Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling

Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling

Keratinocytes are organised into a periodic pattern in feather branching, but how this is regulated is unclear. Here, the authors show that there is a coordinated change in cell shape and adherence, mediated by Notch, FGF signalling and Rho GTPases, which in turn regulates feather branching.

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Autores principales: Dongyang Cheng, Xiaoli Yan, Guofu Qiu, Juan Zhang, Hanwei Wang, Tingting Feng, Yarong Tian, Haiping Xu, Meiqing Wang, Wanzhong He, Ping Wu, Randall B Widelitz, Cheng-Ming Chuong, Zhicao Yue
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/512344d8b95948a59dd73b4be07b7949
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spelling oai:doaj.org-article:512344d8b95948a59dd73b4be07b79492021-12-02T17:33:16ZContraction of basal filopodia controls periodic feather branching via Notch and FGF signaling10.1038/s41467-018-03801-z2041-1723https://doaj.org/article/512344d8b95948a59dd73b4be07b79492018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03801-zhttps://doaj.org/toc/2041-1723Keratinocytes are organised into a periodic pattern in feather branching, but how this is regulated is unclear. Here, the authors show that there is a coordinated change in cell shape and adherence, mediated by Notch, FGF signalling and Rho GTPases, which in turn regulates feather branching.Dongyang ChengXiaoli YanGuofu QiuJuan ZhangHanwei WangTingting FengYarong TianHaiping XuMeiqing WangWanzhong HePing WuRandall B WidelitzCheng-Ming ChuongZhicao YueNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dongyang Cheng
Xiaoli Yan
Guofu Qiu
Juan Zhang
Hanwei Wang
Tingting Feng
Yarong Tian
Haiping Xu
Meiqing Wang
Wanzhong He
Ping Wu
Randall B Widelitz
Cheng-Ming Chuong
Zhicao Yue
Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling
description Keratinocytes are organised into a periodic pattern in feather branching, but how this is regulated is unclear. Here, the authors show that there is a coordinated change in cell shape and adherence, mediated by Notch, FGF signalling and Rho GTPases, which in turn regulates feather branching.
format article
author Dongyang Cheng
Xiaoli Yan
Guofu Qiu
Juan Zhang
Hanwei Wang
Tingting Feng
Yarong Tian
Haiping Xu
Meiqing Wang
Wanzhong He
Ping Wu
Randall B Widelitz
Cheng-Ming Chuong
Zhicao Yue
author_facet Dongyang Cheng
Xiaoli Yan
Guofu Qiu
Juan Zhang
Hanwei Wang
Tingting Feng
Yarong Tian
Haiping Xu
Meiqing Wang
Wanzhong He
Ping Wu
Randall B Widelitz
Cheng-Ming Chuong
Zhicao Yue
author_sort Dongyang Cheng
title Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling
title_short Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling
title_full Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling
title_fullStr Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling
title_full_unstemmed Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling
title_sort contraction of basal filopodia controls periodic feather branching via notch and fgf signaling
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/512344d8b95948a59dd73b4be07b7949
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