Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods

Abstract This review examines the preparation of alginate hydrogel microparticles by using droplet-based microfluidics, a technique widely employed for its ease of use and excellent control of physicochemical properties, with narrow size distribution. The gelation of alginate is realized “on-chip” a...

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Autores principales:	Cheng Zhang, Romain Grossier, Nadine Candoni, Stéphane Veesler
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Alginate Hydrogel Microparticle Crosslinking Droplet-based microfluidics Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/512350cb70554c4e9db05de95681997b
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spelling	oai:doaj.org-article:512350cb70554c4e9db05de95681997b2021-11-28T12:06:10ZPreparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods10.1186/s40824-021-00243-52055-7124https://doaj.org/article/512350cb70554c4e9db05de95681997b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40824-021-00243-5https://doaj.org/toc/2055-7124Abstract This review examines the preparation of alginate hydrogel microparticles by using droplet-based microfluidics, a technique widely employed for its ease of use and excellent control of physicochemical properties, with narrow size distribution. The gelation of alginate is realized “on-chip” and/or “off-chip”, depending on where cross-linkers are introduced. Various strategies are described and compared. Microparticle properties such as size, shape, concentration, stability and mechanical properties are discussed. Finally, we consider future perspectives for the preparation of hydrogel microparticles and their potential applications.Cheng ZhangRomain GrossierNadine CandoniStéphane VeeslerBMCarticleAlginateHydrogelMicroparticleCrosslinkingDroplet-based microfluidicsMedical technologyR855-855.5ENBiomaterials Research, Vol 25, Iss 1, Pp 1-26 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alginate Hydrogel Microparticle Crosslinking Droplet-based microfluidics Medical technology R855-855.5
spellingShingle	Alginate Hydrogel Microparticle Crosslinking Droplet-based microfluidics Medical technology R855-855.5 Cheng Zhang Romain Grossier Nadine Candoni Stéphane Veesler Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods
description	Abstract This review examines the preparation of alginate hydrogel microparticles by using droplet-based microfluidics, a technique widely employed for its ease of use and excellent control of physicochemical properties, with narrow size distribution. The gelation of alginate is realized “on-chip” and/or “off-chip”, depending on where cross-linkers are introduced. Various strategies are described and compared. Microparticle properties such as size, shape, concentration, stability and mechanical properties are discussed. Finally, we consider future perspectives for the preparation of hydrogel microparticles and their potential applications.
format	article
author	Cheng Zhang Romain Grossier Nadine Candoni Stéphane Veesler
author_facet	Cheng Zhang Romain Grossier Nadine Candoni Stéphane Veesler
author_sort	Cheng Zhang
title	Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods
title_short	Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods
title_full	Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods
title_fullStr	Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods
title_full_unstemmed	Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods
title_sort	preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods
publisher	BMC
publishDate	2021
url	https://doaj.org/article/512350cb70554c4e9db05de95681997b
work_keys_str_mv	AT chengzhang preparationofalginatehydrogelmicroparticlesbygelationintroducingcrosslinkersusingdropletbasedmicrofluidicsareviewofmethods AT romaingrossier preparationofalginatehydrogelmicroparticlesbygelationintroducingcrosslinkersusingdropletbasedmicrofluidicsareviewofmethods AT nadinecandoni preparationofalginatehydrogelmicroparticlesbygelationintroducingcrosslinkersusingdropletbasedmicrofluidicsareviewofmethods AT stephaneveesler preparationofalginatehydrogelmicroparticlesbygelationintroducingcrosslinkersusingdropletbasedmicrofluidicsareviewofmethods
_version_	1718408196285005824

Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods

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