The effect of inbreeding, body size and morphology on health in dog breeds

Abstract Background Dog breeds are known for their distinctive body shape, size, coat color, head type and behaviors, features that are relatively similar across members of a breed. Unfortunately, dog breeds are also characterized by distinct predispositions to disease. We explored the relationships...

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Autores principales:	Danika Bannasch, Thomas Famula, Jonas Donner, Heidi Anderson, Leena Honkanen, Kevin Batcher, Noa Safra, Sara Thomasy, Robert Rebhun
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Canine Genetic Inherited Morbidity Mortality Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/512883603d26485a8014994a4f355256
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spelling	oai:doaj.org-article:512883603d26485a8014994a4f3552562021-12-05T12:04:17ZThe effect of inbreeding, body size and morphology on health in dog breeds10.1186/s40575-021-00111-42662-9380https://doaj.org/article/512883603d26485a8014994a4f3552562021-12-01T00:00:00Zhttps://doi.org/10.1186/s40575-021-00111-4https://doaj.org/toc/2662-9380Abstract Background Dog breeds are known for their distinctive body shape, size, coat color, head type and behaviors, features that are relatively similar across members of a breed. Unfortunately, dog breeds are also characterized by distinct predispositions to disease. We explored the relationships between inbreeding, morphology and health using genotype based inbreeding estimates, body weight and insurance data for morbidity. Results The average inbreeding based on genotype across 227 breeds was Fadj = 0.249 (95% CI 0.235–0.263). There were significant differences in morbidity between breeds with low and high inbreeding (H = 16.49, P = 0.0004). There was also a significant difference in morbidity between brachycephalic breeds and non-brachycephalic breeds (P = 0.0048) and between functionally distinct groups of breeds (H = 14.95 P < 0.0001). Morbidity was modeled using robust regression analysis and both body weight (P < 0.0001) and inbreeding (P = 0.013) were significant (r 2 = 0.77). Smaller less inbred breeds were healthier than larger more inbred breeds. Conclusions In this study, body size and inbreeding along with deleterious morphologies contributed to increases in necessary health care in dogs.Danika BannaschThomas FamulaJonas DonnerHeidi AndersonLeena HonkanenKevin BatcherNoa SafraSara ThomasyRobert RebhunBMCarticleCanineGeneticInheritedMorbidityMortalityVeterinary medicineSF600-1100ENCanine Medicine and Genetics, Vol 8, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Canine Genetic Inherited Morbidity Mortality Veterinary medicine SF600-1100
spellingShingle	Canine Genetic Inherited Morbidity Mortality Veterinary medicine SF600-1100 Danika Bannasch Thomas Famula Jonas Donner Heidi Anderson Leena Honkanen Kevin Batcher Noa Safra Sara Thomasy Robert Rebhun The effect of inbreeding, body size and morphology on health in dog breeds
description	Abstract Background Dog breeds are known for their distinctive body shape, size, coat color, head type and behaviors, features that are relatively similar across members of a breed. Unfortunately, dog breeds are also characterized by distinct predispositions to disease. We explored the relationships between inbreeding, morphology and health using genotype based inbreeding estimates, body weight and insurance data for morbidity. Results The average inbreeding based on genotype across 227 breeds was Fadj = 0.249 (95% CI 0.235–0.263). There were significant differences in morbidity between breeds with low and high inbreeding (H = 16.49, P = 0.0004). There was also a significant difference in morbidity between brachycephalic breeds and non-brachycephalic breeds (P = 0.0048) and between functionally distinct groups of breeds (H = 14.95 P < 0.0001). Morbidity was modeled using robust regression analysis and both body weight (P < 0.0001) and inbreeding (P = 0.013) were significant (r 2 = 0.77). Smaller less inbred breeds were healthier than larger more inbred breeds. Conclusions In this study, body size and inbreeding along with deleterious morphologies contributed to increases in necessary health care in dogs.
format	article
author	Danika Bannasch Thomas Famula Jonas Donner Heidi Anderson Leena Honkanen Kevin Batcher Noa Safra Sara Thomasy Robert Rebhun
author_facet	Danika Bannasch Thomas Famula Jonas Donner Heidi Anderson Leena Honkanen Kevin Batcher Noa Safra Sara Thomasy Robert Rebhun
author_sort	Danika Bannasch
title	The effect of inbreeding, body size and morphology on health in dog breeds
title_short	The effect of inbreeding, body size and morphology on health in dog breeds
title_full	The effect of inbreeding, body size and morphology on health in dog breeds
title_fullStr	The effect of inbreeding, body size and morphology on health in dog breeds
title_full_unstemmed	The effect of inbreeding, body size and morphology on health in dog breeds
title_sort	effect of inbreeding, body size and morphology on health in dog breeds
publisher	BMC
publishDate	2021
url	https://doaj.org/article/512883603d26485a8014994a4f355256
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The effect of inbreeding, body size and morphology on health in dog breeds

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