Relationship between BMP2/9 Levels and Spinal Function and Quality of Life in Patients with Severe Scoliosis after PVCR

Objective. To explore the relationship between (bone fusion associated protein) bone morphogenetic protein (BMP)2 and BMP9 and spinal function and quality of life in patients with severe scoliosis after posterior vertebral column resection (PVCR). Methods. 78 cases of severe scoliosis treated with P...

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Autores principales:	Quan Li, Zhi Zhao, Jingming Xie, Ying Zhang, Tao Li, Yingsong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/512df765f7604b41a416456ec25de15c
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spelling	oai:doaj.org-article:512df765f7604b41a416456ec25de15c2021-11-08T02:36:48ZRelationship between BMP2/9 Levels and Spinal Function and Quality of Life in Patients with Severe Scoliosis after PVCR1741-428810.1155/2021/7008898https://doaj.org/article/512df765f7604b41a416456ec25de15c2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7008898https://doaj.org/toc/1741-4288Objective. To explore the relationship between (bone fusion associated protein) bone morphogenetic protein (BMP)2 and BMP9 and spinal function and quality of life in patients with severe scoliosis after posterior vertebral column resection (PVCR). Methods. 78 cases of severe scoliosis treated with PVCR surgery in our hospital from January 2015 to April 2018 were selected and set as the observation group, and 80 health examiners in the same period were selected and set as the control group. The ELISA method was used to detect the levels of BMP2 and BMP9 in the two groups. Also, the relationship between the recovery of spinal function, quality of life, and serum BMP2 and BMP9 in the observation group was analyzed. The receiver operating characteristic curve was used to evaluate the predictive value of BMP2 and BMP9 for complications after PVCR. Results. One month after PVCR, the serum BMP2 and BMP9 levels of patients with severe scoliosis were higher than those of healthy people P<0.05. One year after PVCR, Pearson correlation analysis showed that serum levels of BMP2 and BMP9 in patients with scoliosis were positively correlated with ODI scores (r = 0.778, P<0.001; r = 0.746, P<0.001), SRS-22 scores (r = 0.758, P<0.001; r = 0.722, P<0.001), and Cobb angle correction rate (r = 0.838, P<0.001; r = 0.802, P<0.001). Conclusion. The levels of BMP2 and BMP9 of patients with scoliosis after PVCR are higher than those of healthy people. After 1-year follow-up, the patients’ serum BMP2 and BMP9 levels were positively correlated with spinal function recovery, quality of life, and surgical efficacy. Among them, BMP2 and BMP9 had the highest correlation with PVCR surgical efficacy. Paying attention to the serum BMP2 and BMP9 levels of patients with scoliosis has certain clinical significance.Quan LiZhi ZhaoJingming XieYing ZhangTao LiYingsong WangHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Quan Li Zhi Zhao Jingming Xie Ying Zhang Tao Li Yingsong Wang Relationship between BMP2/9 Levels and Spinal Function and Quality of Life in Patients with Severe Scoliosis after PVCR
description	Objective. To explore the relationship between (bone fusion associated protein) bone morphogenetic protein (BMP)2 and BMP9 and spinal function and quality of life in patients with severe scoliosis after posterior vertebral column resection (PVCR). Methods. 78 cases of severe scoliosis treated with PVCR surgery in our hospital from January 2015 to April 2018 were selected and set as the observation group, and 80 health examiners in the same period were selected and set as the control group. The ELISA method was used to detect the levels of BMP2 and BMP9 in the two groups. Also, the relationship between the recovery of spinal function, quality of life, and serum BMP2 and BMP9 in the observation group was analyzed. The receiver operating characteristic curve was used to evaluate the predictive value of BMP2 and BMP9 for complications after PVCR. Results. One month after PVCR, the serum BMP2 and BMP9 levels of patients with severe scoliosis were higher than those of healthy people P<0.05. One year after PVCR, Pearson correlation analysis showed that serum levels of BMP2 and BMP9 in patients with scoliosis were positively correlated with ODI scores (r = 0.778, P<0.001; r = 0.746, P<0.001), SRS-22 scores (r = 0.758, P<0.001; r = 0.722, P<0.001), and Cobb angle correction rate (r = 0.838, P<0.001; r = 0.802, P<0.001). Conclusion. The levels of BMP2 and BMP9 of patients with scoliosis after PVCR are higher than those of healthy people. After 1-year follow-up, the patients’ serum BMP2 and BMP9 levels were positively correlated with spinal function recovery, quality of life, and surgical efficacy. Among them, BMP2 and BMP9 had the highest correlation with PVCR surgical efficacy. Paying attention to the serum BMP2 and BMP9 levels of patients with scoliosis has certain clinical significance.
format	article
author	Quan Li Zhi Zhao Jingming Xie Ying Zhang Tao Li Yingsong Wang
author_facet	Quan Li Zhi Zhao Jingming Xie Ying Zhang Tao Li Yingsong Wang
author_sort	Quan Li
title	Relationship between BMP2/9 Levels and Spinal Function and Quality of Life in Patients with Severe Scoliosis after PVCR
title_short	Relationship between BMP2/9 Levels and Spinal Function and Quality of Life in Patients with Severe Scoliosis after PVCR
title_full	Relationship between BMP2/9 Levels and Spinal Function and Quality of Life in Patients with Severe Scoliosis after PVCR
title_fullStr	Relationship between BMP2/9 Levels and Spinal Function and Quality of Life in Patients with Severe Scoliosis after PVCR
title_full_unstemmed	Relationship between BMP2/9 Levels and Spinal Function and Quality of Life in Patients with Severe Scoliosis after PVCR
title_sort	relationship between bmp2/9 levels and spinal function and quality of life in patients with severe scoliosis after pvcr
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/512df765f7604b41a416456ec25de15c
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Relationship between BMP2/9 Levels and Spinal Function and Quality of Life in Patients with Severe Scoliosis after PVCR

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