Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China

Zheng Xia,1,* Yazhuo Hu,1,* Zhitao Han,1 Ya Gao,1 Jie Bai,2 Yao He,1 Hua Zhao,3 Honghong Zhang1 1Institute of Geriatrics, Beijing Key Laboratory of Normal Aging and Geriatrics, 2Cinical Laboratory in South Building, Chinese PLA General Hospital & Chinese PLA Medical Academy, Beijing, China;...

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Autores principales:	Xia Z, Hu YZ, Han ZT, Gao Y, Bai J, He Y, Zhao H, Zhang H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	vitamin D receptor(VDR) diabetes dyslipidemias polymorphism elderly Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/5130aa0af7b041d9bdc2c697df2703cf
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spelling	oai:doaj.org-article:5130aa0af7b041d9bdc2c697df2703cf2021-12-02T07:30:13ZAssociation of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China1178-1998https://doaj.org/article/5130aa0af7b041d9bdc2c697df2703cf2017-10-01T00:00:00Zhttps://www.dovepress.com/association-of-vitamin-d-receptor-gene-polymorphisms-with-diabetic-dys-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Zheng Xia,1,* Yazhuo Hu,1,* Zhitao Han,1 Ya Gao,1 Jie Bai,2 Yao He,1 Hua Zhao,3 Honghong Zhang1 1Institute of Geriatrics, Beijing Key Laboratory of Normal Aging and Geriatrics, 2Cinical Laboratory in South Building, Chinese PLA General Hospital & Chinese PLA Medical Academy, Beijing, China; 3Zhantansi Outpatient Department, Chinese PLA 309 Hospital, Beijing, China *These authors contributed equally to this work Background: The prevalence of dyslipidemia is rising alarmingly in elderly Han Chinese male patients with type 2 diabetes mellitus (T2DM). The genetic factors that contribute to the development of diabetic dyslipidemia remain incompletely identified. This study was conducted to assess the association between vitamin D receptor (VDR) polymorphisms and development of dyslipidemia in the Han elderly male population with T2DM in North China.Methods: A total of 242 T2DM patients with dyslipidemia (DH group, n=108) or without dyslipidemia (DO group, n=134) and 100 controls were genotyped for ApaI, TaqI and FokI single nucleotide polymorphisms (SNPs) of the VDR gene using polymerase chain reaction-restriction fragment length polymorphism and sequencing. The frequency and distribution of the SNPs were compared between cases and controls.Results: The distribution of genotypes of VDR-FokI was significantly different between the control and DM group (P=0.033), as well as between the control and DH subgroup (P=0.011) but not DO subgroup (P=0.111). The frequency of C allele and CC genotype of FokI was significantly higher in the DH patients than in the controls (P=0.015 and P=0.003, respectively). Logistic regression analysis in a dominant model homozygous for the C allele of the FokI SNP showed that CC genotype was associated with DH patients (OR =1.797, 95% CI: 1.077–2.999, P=0.025). Significant associations of the ApaI and TaqI SNPs with either DO or DH subjects were not observed.Conclusion: These findings suggest that CC genotype of VDR-FokI is a risk factor for T2DM patients with dyslipidemia in elderly males in North China. Keywords: vitamin D receptor, VDR, diabetes, dyslipidemia, polymorphism, elderlyXia ZHu YZHan ZTGao YBai JHe YZhao HZhang HDove Medical Pressarticlevitamin D receptor(VDR)diabetesdyslipidemiaspolymorphismelderlyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 1673-1679 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin D receptor(VDR) diabetes dyslipidemias polymorphism elderly Geriatrics RC952-954.6
spellingShingle	vitamin D receptor(VDR) diabetes dyslipidemias polymorphism elderly Geriatrics RC952-954.6 Xia Z Hu YZ Han ZT Gao Y Bai J He Y Zhao H Zhang H Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China
description	Zheng Xia,1,* Yazhuo Hu,1,* Zhitao Han,1 Ya Gao,1 Jie Bai,2 Yao He,1 Hua Zhao,3 Honghong Zhang1 1Institute of Geriatrics, Beijing Key Laboratory of Normal Aging and Geriatrics, 2Cinical Laboratory in South Building, Chinese PLA General Hospital & Chinese PLA Medical Academy, Beijing, China; 3Zhantansi Outpatient Department, Chinese PLA 309 Hospital, Beijing, China *These authors contributed equally to this work Background: The prevalence of dyslipidemia is rising alarmingly in elderly Han Chinese male patients with type 2 diabetes mellitus (T2DM). The genetic factors that contribute to the development of diabetic dyslipidemia remain incompletely identified. This study was conducted to assess the association between vitamin D receptor (VDR) polymorphisms and development of dyslipidemia in the Han elderly male population with T2DM in North China.Methods: A total of 242 T2DM patients with dyslipidemia (DH group, n=108) or without dyslipidemia (DO group, n=134) and 100 controls were genotyped for ApaI, TaqI and FokI single nucleotide polymorphisms (SNPs) of the VDR gene using polymerase chain reaction-restriction fragment length polymorphism and sequencing. The frequency and distribution of the SNPs were compared between cases and controls.Results: The distribution of genotypes of VDR-FokI was significantly different between the control and DM group (P=0.033), as well as between the control and DH subgroup (P=0.011) but not DO subgroup (P=0.111). The frequency of C allele and CC genotype of FokI was significantly higher in the DH patients than in the controls (P=0.015 and P=0.003, respectively). Logistic regression analysis in a dominant model homozygous for the C allele of the FokI SNP showed that CC genotype was associated with DH patients (OR =1.797, 95% CI: 1.077–2.999, P=0.025). Significant associations of the ApaI and TaqI SNPs with either DO or DH subjects were not observed.Conclusion: These findings suggest that CC genotype of VDR-FokI is a risk factor for T2DM patients with dyslipidemia in elderly males in North China. Keywords: vitamin D receptor, VDR, diabetes, dyslipidemia, polymorphism, elderly
format	article
author	Xia Z Hu YZ Han ZT Gao Y Bai J He Y Zhao H Zhang H
author_facet	Xia Z Hu YZ Han ZT Gao Y Bai J He Y Zhao H Zhang H
author_sort	Xia Z
title	Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China
title_short	Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China
title_full	Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China
title_fullStr	Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China
title_full_unstemmed	Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China
title_sort	association of vitamin d receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in north china
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/5130aa0af7b041d9bdc2c697df2703cf
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Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China

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