Elevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults

Lina Ma, Guiming Sha, Yaxin Zhang, Yun Li Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing 100053, China Purpose: Frailty is associated with adverse health outcomes. Its biological markers are essenti...

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Autores principales:	Ma L, Sha G, Zhang Y, Li Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	adipokine adiponectin biomarker frailty inflammation interleukin-6 Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/51333237d0bb46b782d182310c285ea4
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spelling	oai:doaj.org-article:51333237d0bb46b782d182310c285ea42021-12-02T07:45:21ZElevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults1178-1998https://doaj.org/article/51333237d0bb46b782d182310c285ea42018-10-01T00:00:00Zhttps://www.dovepress.com/elevated-serum-il-6-and-adiponectin-levels-are-associated-with-frailty-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Lina Ma, Guiming Sha, Yaxin Zhang, Yun Li Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing 100053, China Purpose: Frailty is associated with adverse health outcomes. Its biological markers are essential to enhance diagnostic ease and would contribute to surveillance of the condition. Considering the involvement of pro-inflammatory and nutritional states in frailty, we aimed to investigate whether inflammatory mediators and adipokines are associated with frailty and their relationship with physical function. Patients and methods: We recruited 130 older adults (90 nonfrail participants and 40 frail participants, mean age: 72.80±8.61 years) who underwent a comprehensive medical history and frailty assessment. The biochemical indicators (eg, blood urea nitrogen [BUN], high-density lipoprotein [HDL], and hemoglobin [HGB]), insulin pathway (glucose, insulin, and insulin-like growth factor 1 [IGF-1]), circulating inflammatory biomarkers (IL-6, tumor necrosis factor receptor 1, and C-reactive protein), and adipokines (adiponectin, vaspin, and leptin) were compared between the two groups. We further analyzed their correlation with physical function. Results: Frail older adults showed higher levels of BUN, IL-6, adiponectin, vaspin, and glucose and lower levels of IGF-1, HDL, and HGB compared with nonfrail participants. Serum IL-6 levels were negatively correlated with both grip strength (P=0.03) and gait speed (P=0.04). Levels of circulating adiponectin and leptin were adversely correlated with grip strength (P=0.01) and gait speed (P=0.03), respectively. After adjustment for age and sex, the only markers correlated with physical function were IL-6 (r=-0.180, P=0.044) and adiponectin (r=-0.195, P=0.029). Conclusion: High levels of IL-6, adiponectin, vaspin, and glucose as well as low levels of IGF-1 were found in frail older adults. Furthermore, IL-6, adiponectin, and leptin levels were negatively correlated with physical function, suggesting that inflammatory mediators and adipokines are biomarkers for frailty and decreased function in older adults. Keywords: adipokine, adiponectin, biomarker, frailty, inflammation, IL-6Ma LSha GZhang YLi YDove Medical Pressarticleadipokineadiponectinbiomarkerfrailtyinflammationinterleukin-6GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 2013-2020 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	adipokine adiponectin biomarker frailty inflammation interleukin-6 Geriatrics RC952-954.6
spellingShingle	adipokine adiponectin biomarker frailty inflammation interleukin-6 Geriatrics RC952-954.6 Ma L Sha G Zhang Y Li Y Elevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults
description	Lina Ma, Guiming Sha, Yaxin Zhang, Yun Li Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing 100053, China Purpose: Frailty is associated with adverse health outcomes. Its biological markers are essential to enhance diagnostic ease and would contribute to surveillance of the condition. Considering the involvement of pro-inflammatory and nutritional states in frailty, we aimed to investigate whether inflammatory mediators and adipokines are associated with frailty and their relationship with physical function. Patients and methods: We recruited 130 older adults (90 nonfrail participants and 40 frail participants, mean age: 72.80±8.61 years) who underwent a comprehensive medical history and frailty assessment. The biochemical indicators (eg, blood urea nitrogen [BUN], high-density lipoprotein [HDL], and hemoglobin [HGB]), insulin pathway (glucose, insulin, and insulin-like growth factor 1 [IGF-1]), circulating inflammatory biomarkers (IL-6, tumor necrosis factor receptor 1, and C-reactive protein), and adipokines (adiponectin, vaspin, and leptin) were compared between the two groups. We further analyzed their correlation with physical function. Results: Frail older adults showed higher levels of BUN, IL-6, adiponectin, vaspin, and glucose and lower levels of IGF-1, HDL, and HGB compared with nonfrail participants. Serum IL-6 levels were negatively correlated with both grip strength (P=0.03) and gait speed (P=0.04). Levels of circulating adiponectin and leptin were adversely correlated with grip strength (P=0.01) and gait speed (P=0.03), respectively. After adjustment for age and sex, the only markers correlated with physical function were IL-6 (r=-0.180, P=0.044) and adiponectin (r=-0.195, P=0.029). Conclusion: High levels of IL-6, adiponectin, vaspin, and glucose as well as low levels of IGF-1 were found in frail older adults. Furthermore, IL-6, adiponectin, and leptin levels were negatively correlated with physical function, suggesting that inflammatory mediators and adipokines are biomarkers for frailty and decreased function in older adults. Keywords: adipokine, adiponectin, biomarker, frailty, inflammation, IL-6
format	article
author	Ma L Sha G Zhang Y Li Y
author_facet	Ma L Sha G Zhang Y Li Y
author_sort	Ma L
title	Elevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults
title_short	Elevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults
title_full	Elevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults
title_fullStr	Elevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults
title_full_unstemmed	Elevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults
title_sort	elevated serum il-6 and adiponectin levels are associated with frailty and physical function in chinese older adults
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/51333237d0bb46b782d182310c285ea4
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Elevated serum Il-6 and adiponectin levels are associated with frailty and physical function in Chinese older adults

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