Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population.

<h4>Context</h4>Both longer habitual day napping and Non-Alcoholic Fatty Liver Disease (NAFLD) are associated with diabetes and inflammation, but the association between day napping and NAFLD remains unexplored.<h4>Objective</h4>To investigate the association between the dura...

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Autores principales:	Hua Qu, Hang Wang, Min Deng, Huili Wei, Huacong Deng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5136bdb9f3ce463188a9d06432111c17
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spelling	oai:doaj.org-article:5136bdb9f3ce463188a9d06432111c172021-11-25T06:04:01ZAssociations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population.1932-620310.1371/journal.pone.0105583https://doaj.org/article/5136bdb9f3ce463188a9d06432111c172014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25140521/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Context</h4>Both longer habitual day napping and Non-Alcoholic Fatty Liver Disease (NAFLD) are associated with diabetes and inflammation, but the association between day napping and NAFLD remains unexplored.<h4>Objective</h4>To investigate the association between the duration of habitual day napping and NAFLD in an elderly Chinese population and to gain insight into the role of inflammatory cytokines in this association.<h4>Design and setting</h4>We conducted a series of cross-sectional studies of the community population in Chongqing, China, from 2011 to 2012.<h4>Participants</h4>Among 6998 participants aged 40 to 75 years, 6438 eligible participants were included in the first study and analyzed to observe the association between day napping duration and NAFLD. In a separate study, 80 non-nappers and 90 nappers were selected to identify the role of inflammatory cytokines in this association. Logistic regression models were used to examine the odds ratios (ORs) of day nap duration with NAFLD.<h4>Results</h4>Day nappers had a significantly higher prevalence of NAFLD (P<0.001). Longer day napping duration was associated in a dose-dependent manner with NAFLD (P trend <0.001). After adjustment for potential confounders, the ORs were 1.67 (95% CI 1.13-2.46) for those reporting 0.5-1 h and 1.49 (95% CI 1.01-2.19) for those reporting >1 h of day napping compared with individuals who did not take day naps (all P<0.05). Longer-duration day nappers had higher levels of IL-6 and progranulin (PGRN) but lower levels of Secreted frizzled-related protein-5 (SFRP5, all P trend <0.001). After adjusting for IL-6, PGRN, and SFRP5, the association between day napping duration and NAFLD disappeared (all P>0.05).<h4>Conclusion</h4>Longer day napping duration is associated with a higher prevalence of NAFLD, and inflammatory cytokines may be an essential link between day napping and NAFLD.Hua QuHang WangMin DengHuili WeiHuacong DengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105583 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hua Qu Hang Wang Min Deng Huili Wei Huacong Deng Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population.
description	<h4>Context</h4>Both longer habitual day napping and Non-Alcoholic Fatty Liver Disease (NAFLD) are associated with diabetes and inflammation, but the association between day napping and NAFLD remains unexplored.<h4>Objective</h4>To investigate the association between the duration of habitual day napping and NAFLD in an elderly Chinese population and to gain insight into the role of inflammatory cytokines in this association.<h4>Design and setting</h4>We conducted a series of cross-sectional studies of the community population in Chongqing, China, from 2011 to 2012.<h4>Participants</h4>Among 6998 participants aged 40 to 75 years, 6438 eligible participants were included in the first study and analyzed to observe the association between day napping duration and NAFLD. In a separate study, 80 non-nappers and 90 nappers were selected to identify the role of inflammatory cytokines in this association. Logistic regression models were used to examine the odds ratios (ORs) of day nap duration with NAFLD.<h4>Results</h4>Day nappers had a significantly higher prevalence of NAFLD (P<0.001). Longer day napping duration was associated in a dose-dependent manner with NAFLD (P trend <0.001). After adjustment for potential confounders, the ORs were 1.67 (95% CI 1.13-2.46) for those reporting 0.5-1 h and 1.49 (95% CI 1.01-2.19) for those reporting >1 h of day napping compared with individuals who did not take day naps (all P<0.05). Longer-duration day nappers had higher levels of IL-6 and progranulin (PGRN) but lower levels of Secreted frizzled-related protein-5 (SFRP5, all P trend <0.001). After adjusting for IL-6, PGRN, and SFRP5, the association between day napping duration and NAFLD disappeared (all P>0.05).<h4>Conclusion</h4>Longer day napping duration is associated with a higher prevalence of NAFLD, and inflammatory cytokines may be an essential link between day napping and NAFLD.
format	article
author	Hua Qu Hang Wang Min Deng Huili Wei Huacong Deng
author_facet	Hua Qu Hang Wang Min Deng Huili Wei Huacong Deng
author_sort	Hua Qu
title	Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population.
title_short	Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population.
title_full	Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population.
title_fullStr	Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population.
title_full_unstemmed	Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population.
title_sort	associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly chinese population.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5136bdb9f3ce463188a9d06432111c17
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Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population.

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