Lung cancer risk in non-smoking females with a familial history of cancer: a multi-center prospective cohort study in China

ABSTRACT: Familial risk of lung cancer has been widely studied but whether this association holds in non-smoking females is largely unknown. We sought to determine the relationship between a family history of cancer and lung cancer risk among Chinese non-smoking females based on a multi-center prosp...

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Autores principales:	Fei Wang, Fengwei Tan, Zheng Wu, Wei Cao, Zhuoyu Yang, Yiwen Yu, Yongjie Xu, Chao Qin, Liang Zhao, Jiansong Ren, Jiang Li, Wanqing Chen, Ni Li, Jie He
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Lung cancer Family history Risk factor Non-smoking female Cancer screening Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/51373c9b79ad45748661d4629805c740
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spelling	oai:doaj.org-article:51373c9b79ad45748661d4629805c7402021-12-01T05:06:48ZLung cancer risk in non-smoking females with a familial history of cancer: a multi-center prospective cohort study in China2667-005410.1016/j.jncc.2021.07.002https://doaj.org/article/51373c9b79ad45748661d4629805c7402021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667005421000314https://doaj.org/toc/2667-0054ABSTRACT: Familial risk of lung cancer has been widely studied but whether this association holds in non-smoking females is largely unknown. We sought to determine the relationship between a family history of cancer and lung cancer risk among Chinese non-smoking females based on a multi-center prospective population-based cohort study involving 547,218 individuals between 2013 and 2019. A total of 1620 lung cancer cases occurred during a median follow-up of 3.9 years. Multivariable Cox regression showed that a family history of lung cancer in first-degree relatives significantly increased the risk of lung cancer (HR: 1.50, 95%CI: 1.29, 1.75, P<0.001). Relative to those with no relatives affected, the risk of lung cancer was 51% higher in females with one relative affected (HR: 1.51, 95%CI: 1.29-1.76, P<0.001), 123% higher in females with two relatives affected (HR: 2.23, 95%CI: 1.57-3.15, P<0.001) and 143% higher in females with three or more relatives affected (HR: 2.43, 95%CI: 1.21-4.91, P=0.013). Two nested case control studies stratified by age at diagnosis were conducted to verify potential disparities in this association between the early or late onset of lung cancer. A family history of lung cancer in first-degree relatives was significantly correlated with an elevated risk of lung cancer for both cases before and after age 65 (OR: 1.36, 95%CI: 1.07-1.74, P=0.013; OR: 1.64, 95%CI: 1.15-2.33, P=0.006). Our analysis confirmed the importance of familial history of cancers on lung cancer risk in non-smoking females and highlighted the possibility of interaction between genetic and environmental effect on lung cancer.Fei WangFengwei TanZheng WuWei CaoZhuoyu YangYiwen YuYongjie XuChao QinLiang ZhaoJiansong RenJiang LiWanqing ChenNi LiJie HeElsevierarticleLung cancerFamily historyRisk factorNon-smoking femaleCancer screeningNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of the National Cancer Center, Vol 1, Iss 3, Pp 108-114 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lung cancer Family history Risk factor Non-smoking female Cancer screening Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Lung cancer Family history Risk factor Non-smoking female Cancer screening Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Fei Wang Fengwei Tan Zheng Wu Wei Cao Zhuoyu Yang Yiwen Yu Yongjie Xu Chao Qin Liang Zhao Jiansong Ren Jiang Li Wanqing Chen Ni Li Jie He Lung cancer risk in non-smoking females with a familial history of cancer: a multi-center prospective cohort study in China
description	ABSTRACT: Familial risk of lung cancer has been widely studied but whether this association holds in non-smoking females is largely unknown. We sought to determine the relationship between a family history of cancer and lung cancer risk among Chinese non-smoking females based on a multi-center prospective population-based cohort study involving 547,218 individuals between 2013 and 2019. A total of 1620 lung cancer cases occurred during a median follow-up of 3.9 years. Multivariable Cox regression showed that a family history of lung cancer in first-degree relatives significantly increased the risk of lung cancer (HR: 1.50, 95%CI: 1.29, 1.75, P<0.001). Relative to those with no relatives affected, the risk of lung cancer was 51% higher in females with one relative affected (HR: 1.51, 95%CI: 1.29-1.76, P<0.001), 123% higher in females with two relatives affected (HR: 2.23, 95%CI: 1.57-3.15, P<0.001) and 143% higher in females with three or more relatives affected (HR: 2.43, 95%CI: 1.21-4.91, P=0.013). Two nested case control studies stratified by age at diagnosis were conducted to verify potential disparities in this association between the early or late onset of lung cancer. A family history of lung cancer in first-degree relatives was significantly correlated with an elevated risk of lung cancer for both cases before and after age 65 (OR: 1.36, 95%CI: 1.07-1.74, P=0.013; OR: 1.64, 95%CI: 1.15-2.33, P=0.006). Our analysis confirmed the importance of familial history of cancers on lung cancer risk in non-smoking females and highlighted the possibility of interaction between genetic and environmental effect on lung cancer.
format	article
author	Fei Wang Fengwei Tan Zheng Wu Wei Cao Zhuoyu Yang Yiwen Yu Yongjie Xu Chao Qin Liang Zhao Jiansong Ren Jiang Li Wanqing Chen Ni Li Jie He
author_facet	Fei Wang Fengwei Tan Zheng Wu Wei Cao Zhuoyu Yang Yiwen Yu Yongjie Xu Chao Qin Liang Zhao Jiansong Ren Jiang Li Wanqing Chen Ni Li Jie He
author_sort	Fei Wang
title	Lung cancer risk in non-smoking females with a familial history of cancer: a multi-center prospective cohort study in China
title_short	Lung cancer risk in non-smoking females with a familial history of cancer: a multi-center prospective cohort study in China
title_full	Lung cancer risk in non-smoking females with a familial history of cancer: a multi-center prospective cohort study in China
title_fullStr	Lung cancer risk in non-smoking females with a familial history of cancer: a multi-center prospective cohort study in China
title_full_unstemmed	Lung cancer risk in non-smoking females with a familial history of cancer: a multi-center prospective cohort study in China
title_sort	lung cancer risk in non-smoking females with a familial history of cancer: a multi-center prospective cohort study in china
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/51373c9b79ad45748661d4629805c740
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Lung cancer risk in non-smoking females with a familial history of cancer: a multi-center prospective cohort study in China

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