Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic

Progressive multiple sclerosis is an inflammatory and degenerative disease of the central nervous system, for which effective treatment is lacking. The authors carry out a screen to identify orally available generic medications, and show that the antidepressant clomipramine reduces pathology in mous...

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Autores principales:	Simon Faissner, Manoj Mishra, Deepak K. Kaushik, Jianxiong Wang, Yan Fan, Claudia Silva, Gail Rauw, Luanne Metz, Marcus Koch, V. Wee Yong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5138f03dd48544af82faa46f48eca8b2
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spelling	oai:doaj.org-article:5138f03dd48544af82faa46f48eca8b22021-12-02T14:41:21ZSystematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic10.1038/s41467-017-02119-62041-1723https://doaj.org/article/5138f03dd48544af82faa46f48eca8b22017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02119-6https://doaj.org/toc/2041-1723Progressive multiple sclerosis is an inflammatory and degenerative disease of the central nervous system, for which effective treatment is lacking. The authors carry out a screen to identify orally available generic medications, and show that the antidepressant clomipramine reduces pathology in mouse models.Simon FaissnerManoj MishraDeepak K. KaushikJianxiong WangYan FanClaudia SilvaGail RauwLuanne MetzMarcus KochV. Wee YongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon Faissner Manoj Mishra Deepak K. Kaushik Jianxiong Wang Yan Fan Claudia Silva Gail Rauw Luanne Metz Marcus Koch V. Wee Yong Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic
description	Progressive multiple sclerosis is an inflammatory and degenerative disease of the central nervous system, for which effective treatment is lacking. The authors carry out a screen to identify orally available generic medications, and show that the antidepressant clomipramine reduces pathology in mouse models.
format	article
author	Simon Faissner Manoj Mishra Deepak K. Kaushik Jianxiong Wang Yan Fan Claudia Silva Gail Rauw Luanne Metz Marcus Koch V. Wee Yong
author_facet	Simon Faissner Manoj Mishra Deepak K. Kaushik Jianxiong Wang Yan Fan Claudia Silva Gail Rauw Luanne Metz Marcus Koch V. Wee Yong
author_sort	Simon Faissner
title	Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic
title_short	Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic
title_full	Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic
title_fullStr	Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic
title_full_unstemmed	Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic
title_sort	systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5138f03dd48544af82faa46f48eca8b2
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Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic

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