WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression

The biological functions of WSX1, the alpha subunit of the interleukin-27 receptor, in non-immune cells are largely unknown. Here, the authors propose an IL-27-independent tumor suppressor role for WSX1 in hepatocytes, showing that WSX1 restricts tumor progression by down-regulating PD-L1 expression...

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Autores principales:	Man Wu, Xueqing Xia, Jiemiao Hu, Natalie Wall Fowlkes, Shulin Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/51393f02d5054a7ea8bbacf798de9020
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spelling	oai:doaj.org-article:51393f02d5054a7ea8bbacf798de90202021-12-02T17:52:09ZWSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression10.1038/s41467-021-23864-92041-1723https://doaj.org/article/51393f02d5054a7ea8bbacf798de90202021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23864-9https://doaj.org/toc/2041-1723The biological functions of WSX1, the alpha subunit of the interleukin-27 receptor, in non-immune cells are largely unknown. Here, the authors propose an IL-27-independent tumor suppressor role for WSX1 in hepatocytes, showing that WSX1 restricts tumor progression by down-regulating PD-L1 expression in tumour cells and maximizing T cell mediated antitumor immune responses.Man WuXueqing XiaJiemiao HuNatalie Wall FowlkesShulin LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Man Wu Xueqing Xia Jiemiao Hu Natalie Wall Fowlkes Shulin Li WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression
description	The biological functions of WSX1, the alpha subunit of the interleukin-27 receptor, in non-immune cells are largely unknown. Here, the authors propose an IL-27-independent tumor suppressor role for WSX1 in hepatocytes, showing that WSX1 restricts tumor progression by down-regulating PD-L1 expression in tumour cells and maximizing T cell mediated antitumor immune responses.
format	article
author	Man Wu Xueqing Xia Jiemiao Hu Natalie Wall Fowlkes Shulin Li
author_facet	Man Wu Xueqing Xia Jiemiao Hu Natalie Wall Fowlkes Shulin Li
author_sort	Man Wu
title	WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression
title_short	WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression
title_full	WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression
title_fullStr	WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression
title_full_unstemmed	WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression
title_sort	wsx1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic pd-l1 expression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/51393f02d5054a7ea8bbacf798de9020
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WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression

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