Association Between MTHFR Polymorphisms and the Risk of Essential Hypertension: An Updated Meta-analysis

Background: Since the 1990s, there have been a lot of research on single-nucleotide polymorphism (SNP) and different diseases, including many studies on 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphism and essential hypertension (EH). Nevertheless, their conclusions were controversial....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hao Meng, Shaoyan Huang, Yali Yang, Xiaofeng He, Liping Fei, Yuping Xing
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	MTHFR Rs1801133 Rs1801131 Essential hypertension FPRP BFDP Genetics QH426-470
Acceso en línea:	https://doaj.org/article/513beca431f74be897195683ae9ea0d6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:513beca431f74be897195683ae9ea0d6
record_format	dspace
spelling	oai:doaj.org-article:513beca431f74be897195683ae9ea0d62021-12-01T08:18:04ZAssociation Between MTHFR Polymorphisms and the Risk of Essential Hypertension: An Updated Meta-analysis1664-802110.3389/fgene.2021.698590https://doaj.org/article/513beca431f74be897195683ae9ea0d62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.698590/fullhttps://doaj.org/toc/1664-8021Background: Since the 1990s, there have been a lot of research on single-nucleotide polymorphism (SNP) and different diseases, including many studies on 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphism and essential hypertension (EH). Nevertheless, their conclusions were controversial. So far, six previous meta-analyses discussed the internal relationship between the MTHFR polymorphism and EH, respectively. However, they did not evaluate the credibility of the positive associations. To build on previous meta-analyses, we updated the literature by including previously included papers as well as nine new articles, improved the inclusion criteria by also considering the quality of the papers, and applied new statistical techniques to assess the observed associations. Objectives: This study aims to explore the degree of risk correlation between two MTHFR polymorphisms and EH. Methods: PubMed, EMBASE, the Cochrane Library, CNKI, and Wan Fang electronic databases were searched to identify relevant studies. We evaluated the relation between the MTHFR C677T (rs1801133) and A1298C (rs1801131) polymorphisms and EH by calculating the odds ratios (OR) as well as 95% confidence intervals (CI). Here we used subgroup analysis, sensitivity analysis, cumulative meta-analysis, assessment of publication bias, meta-regression meta, False-positive report probability (FPRP), Bayesian false discovery probability (BFDP), and Venice criterion. Results: Overall, harboring the variant of MTHFR C677T was associated with an increased risk of EH in the overall populations, East Asians, Southeast Asians, South Asians, Caucasians/Europeans, and Africans. After the sensitivity analysis, positive results were found only in the overall population (TT vs. CC: OR = 1.14, 95% CI: 1.00–1.30, Ph = 0.032, I2 = 39.8%; TT + TC vs. CC: OR = 1.15, 95% CI: 1.01–1.29, Ph = 0.040, I2 = 38.1%; T vs. C: OR = 1.14, 95% CI: 1.04–1.25, Ph = 0.005, I2 = 50.2%) and Asian population (TC vs. CC: OR = 1.14, 95% CI: 1.01–1.28, Ph = 0.265, I2 = 16.8%; TT + TC vs. CC: OR = 1.17, 95% CI: 1.04–1.30, Ph = 0.105, I2 = 32.9%; T vs. C: OR = 1.10, 95% CI: 1.02–1.19, Ph = 0.018, I2 = 48.6%). However, after further statistical assessment by FPRP, BFDP, and Venice criteria, the positive associations reported here could be deemed to be false-positives and present only weak evidence for a causal relationship. In addition, when we performed pooled analysis and sensitivity analysis on MTHFR A1298C; all the results were negative. Conclusion: The positive relationships between MTHFR C677T and A1298C polymorphisms with the susceptibility to present with hypertension were not robust enough to withstand statistical interrogation by FPRP, BFDP, and Venice criteria. Therefore, these SNPs are probably not important in EH etiology.Hao MengShaoyan HuangYali YangXiaofeng HeLiping FeiYuping XingFrontiers Media S.A.articleMTHFRRs1801133Rs1801131Essential hypertensionFPRPBFDPGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MTHFR Rs1801133 Rs1801131 Essential hypertension FPRP BFDP Genetics QH426-470
spellingShingle	MTHFR Rs1801133 Rs1801131 Essential hypertension FPRP BFDP Genetics QH426-470 Hao Meng Shaoyan Huang Yali Yang Xiaofeng He Liping Fei Yuping Xing Association Between MTHFR Polymorphisms and the Risk of Essential Hypertension: An Updated Meta-analysis
description	Background: Since the 1990s, there have been a lot of research on single-nucleotide polymorphism (SNP) and different diseases, including many studies on 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphism and essential hypertension (EH). Nevertheless, their conclusions were controversial. So far, six previous meta-analyses discussed the internal relationship between the MTHFR polymorphism and EH, respectively. However, they did not evaluate the credibility of the positive associations. To build on previous meta-analyses, we updated the literature by including previously included papers as well as nine new articles, improved the inclusion criteria by also considering the quality of the papers, and applied new statistical techniques to assess the observed associations. Objectives: This study aims to explore the degree of risk correlation between two MTHFR polymorphisms and EH. Methods: PubMed, EMBASE, the Cochrane Library, CNKI, and Wan Fang electronic databases were searched to identify relevant studies. We evaluated the relation between the MTHFR C677T (rs1801133) and A1298C (rs1801131) polymorphisms and EH by calculating the odds ratios (OR) as well as 95% confidence intervals (CI). Here we used subgroup analysis, sensitivity analysis, cumulative meta-analysis, assessment of publication bias, meta-regression meta, False-positive report probability (FPRP), Bayesian false discovery probability (BFDP), and Venice criterion. Results: Overall, harboring the variant of MTHFR C677T was associated with an increased risk of EH in the overall populations, East Asians, Southeast Asians, South Asians, Caucasians/Europeans, and Africans. After the sensitivity analysis, positive results were found only in the overall population (TT vs. CC: OR = 1.14, 95% CI: 1.00–1.30, Ph = 0.032, I2 = 39.8%; TT + TC vs. CC: OR = 1.15, 95% CI: 1.01–1.29, Ph = 0.040, I2 = 38.1%; T vs. C: OR = 1.14, 95% CI: 1.04–1.25, Ph = 0.005, I2 = 50.2%) and Asian population (TC vs. CC: OR = 1.14, 95% CI: 1.01–1.28, Ph = 0.265, I2 = 16.8%; TT + TC vs. CC: OR = 1.17, 95% CI: 1.04–1.30, Ph = 0.105, I2 = 32.9%; T vs. C: OR = 1.10, 95% CI: 1.02–1.19, Ph = 0.018, I2 = 48.6%). However, after further statistical assessment by FPRP, BFDP, and Venice criteria, the positive associations reported here could be deemed to be false-positives and present only weak evidence for a causal relationship. In addition, when we performed pooled analysis and sensitivity analysis on MTHFR A1298C; all the results were negative. Conclusion: The positive relationships between MTHFR C677T and A1298C polymorphisms with the susceptibility to present with hypertension were not robust enough to withstand statistical interrogation by FPRP, BFDP, and Venice criteria. Therefore, these SNPs are probably not important in EH etiology.
format	article
author	Hao Meng Shaoyan Huang Yali Yang Xiaofeng He Liping Fei Yuping Xing
author_facet	Hao Meng Shaoyan Huang Yali Yang Xiaofeng He Liping Fei Yuping Xing
author_sort	Hao Meng
title	Association Between MTHFR Polymorphisms and the Risk of Essential Hypertension: An Updated Meta-analysis
title_short	Association Between MTHFR Polymorphisms and the Risk of Essential Hypertension: An Updated Meta-analysis
title_full	Association Between MTHFR Polymorphisms and the Risk of Essential Hypertension: An Updated Meta-analysis
title_fullStr	Association Between MTHFR Polymorphisms and the Risk of Essential Hypertension: An Updated Meta-analysis
title_full_unstemmed	Association Between MTHFR Polymorphisms and the Risk of Essential Hypertension: An Updated Meta-analysis
title_sort	association between mthfr polymorphisms and the risk of essential hypertension: an updated meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/513beca431f74be897195683ae9ea0d6
work_keys_str_mv	AT haomeng associationbetweenmthfrpolymorphismsandtheriskofessentialhypertensionanupdatedmetaanalysis AT shaoyanhuang associationbetweenmthfrpolymorphismsandtheriskofessentialhypertensionanupdatedmetaanalysis AT yaliyang associationbetweenmthfrpolymorphismsandtheriskofessentialhypertensionanupdatedmetaanalysis AT xiaofenghe associationbetweenmthfrpolymorphismsandtheriskofessentialhypertensionanupdatedmetaanalysis AT lipingfei associationbetweenmthfrpolymorphismsandtheriskofessentialhypertensionanupdatedmetaanalysis AT yupingxing associationbetweenmthfrpolymorphismsandtheriskofessentialhypertensionanupdatedmetaanalysis
_version_	1718405353280897024

Association Between MTHFR Polymorphisms and the Risk of Essential Hypertension: An Updated Meta-analysis

Ejemplares similares