Plasma GDF-15 concentration is not elevated in open-angle glaucoma.

<h4>Aim</h4>Recently, the level of growth differentiation factor 15 (GDF-15) in blood, was proposed as biomarker to detect mitochondrial dysfunction. In the current study, we evaluate this biomarker in open-angle glaucoma (OAG), as there is increasing evidence that mitochondrial dysfunct...

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Autores principales:	Wouter H G Hubens, Mariëlle T Kievit, Tos T J M Berendschot, Irenaeus F M de Coo, Hubert J M Smeets, Carroll A B Webers, Theo G M F Gorgels
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/513c16c27d86484db8fc1dd06bdd15d8
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spelling	oai:doaj.org-article:513c16c27d86484db8fc1dd06bdd15d82021-12-02T20:11:12ZPlasma GDF-15 concentration is not elevated in open-angle glaucoma.1932-620310.1371/journal.pone.0252630https://doaj.org/article/513c16c27d86484db8fc1dd06bdd15d82021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252630https://doaj.org/toc/1932-6203<h4>Aim</h4>Recently, the level of growth differentiation factor 15 (GDF-15) in blood, was proposed as biomarker to detect mitochondrial dysfunction. In the current study, we evaluate this biomarker in open-angle glaucoma (OAG), as there is increasing evidence that mitochondrial dysfunction plays a role in the pathophysiology of this disease.<h4>Methods</h4>Plasma GDF-15 concentrations were measured with ELISA in 200 OAG patients and 61 age-matched controls (cataract without glaucoma). The OAG patient group consisted of high tension glaucoma (HTG; n = 162) and normal tension glaucoma (NTG; n = 38). Groups were compared using the Kruskal-Wallis nonparametric test with Dunn's multiple comparison post-hoc correction. GDF-15 concentration was corrected for confounders identified with forward linear regression models.<h4>Results</h4>Before correcting for confounders, median plasma GDF-15 levels was significantly lower in the combined OAG group (p = 0.04), but not when analysing HTG and NTG patients separately. Forward linear regression analysis showed that age, gender, smoking and systemic hypertension were significant confounders affecting GDF-15 levels. After correction for these confounders, GDF-15 levels in OAG patients were no longer significantly different from controls. Subgroup analysis of the glaucoma patients did not show a correlation between disease severity and plasma GDF-15, but did reveal that for NTG patients, intake of dietary supplements, which potentially improve mitochondrial function, correlated with lower plasma GDF-15.<h4>Conclusion</h4>The present study suggests that plasma GDF-15 is not suited as biomarker of mitochondrial dysfunction in OAG patients.Wouter H G HubensMariëlle T KievitTos T J M BerendschotIrenaeus F M de CooHubert J M SmeetsCarroll A B WebersTheo G M F GorgelsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0252630 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wouter H G Hubens Mariëlle T Kievit Tos T J M Berendschot Irenaeus F M de Coo Hubert J M Smeets Carroll A B Webers Theo G M F Gorgels Plasma GDF-15 concentration is not elevated in open-angle glaucoma.
description	<h4>Aim</h4>Recently, the level of growth differentiation factor 15 (GDF-15) in blood, was proposed as biomarker to detect mitochondrial dysfunction. In the current study, we evaluate this biomarker in open-angle glaucoma (OAG), as there is increasing evidence that mitochondrial dysfunction plays a role in the pathophysiology of this disease.<h4>Methods</h4>Plasma GDF-15 concentrations were measured with ELISA in 200 OAG patients and 61 age-matched controls (cataract without glaucoma). The OAG patient group consisted of high tension glaucoma (HTG; n = 162) and normal tension glaucoma (NTG; n = 38). Groups were compared using the Kruskal-Wallis nonparametric test with Dunn's multiple comparison post-hoc correction. GDF-15 concentration was corrected for confounders identified with forward linear regression models.<h4>Results</h4>Before correcting for confounders, median plasma GDF-15 levels was significantly lower in the combined OAG group (p = 0.04), but not when analysing HTG and NTG patients separately. Forward linear regression analysis showed that age, gender, smoking and systemic hypertension were significant confounders affecting GDF-15 levels. After correction for these confounders, GDF-15 levels in OAG patients were no longer significantly different from controls. Subgroup analysis of the glaucoma patients did not show a correlation between disease severity and plasma GDF-15, but did reveal that for NTG patients, intake of dietary supplements, which potentially improve mitochondrial function, correlated with lower plasma GDF-15.<h4>Conclusion</h4>The present study suggests that plasma GDF-15 is not suited as biomarker of mitochondrial dysfunction in OAG patients.
format	article
author	Wouter H G Hubens Mariëlle T Kievit Tos T J M Berendschot Irenaeus F M de Coo Hubert J M Smeets Carroll A B Webers Theo G M F Gorgels
author_facet	Wouter H G Hubens Mariëlle T Kievit Tos T J M Berendschot Irenaeus F M de Coo Hubert J M Smeets Carroll A B Webers Theo G M F Gorgels
author_sort	Wouter H G Hubens
title	Plasma GDF-15 concentration is not elevated in open-angle glaucoma.
title_short	Plasma GDF-15 concentration is not elevated in open-angle glaucoma.
title_full	Plasma GDF-15 concentration is not elevated in open-angle glaucoma.
title_fullStr	Plasma GDF-15 concentration is not elevated in open-angle glaucoma.
title_full_unstemmed	Plasma GDF-15 concentration is not elevated in open-angle glaucoma.
title_sort	plasma gdf-15 concentration is not elevated in open-angle glaucoma.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/513c16c27d86484db8fc1dd06bdd15d8
work_keys_str_mv	AT wouterhghubens plasmagdf15concentrationisnotelevatedinopenangleglaucoma AT marielletkievit plasmagdf15concentrationisnotelevatedinopenangleglaucoma AT tostjmberendschot plasmagdf15concentrationisnotelevatedinopenangleglaucoma AT irenaeusfmdecoo plasmagdf15concentrationisnotelevatedinopenangleglaucoma AT hubertjmsmeets plasmagdf15concentrationisnotelevatedinopenangleglaucoma AT carrollabwebers plasmagdf15concentrationisnotelevatedinopenangleglaucoma AT theogmfgorgels plasmagdf15concentrationisnotelevatedinopenangleglaucoma
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Plasma GDF-15 concentration is not elevated in open-angle glaucoma.

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