The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status.

<h4>Background</h4>Research suggests that the COMT Val(158)Met, BDNF Val(66)Met and OPRM1 A(118)G polymorphisms moderate the experience of pain. In order to obtain experimental confirmation and extension of findings, cortical processing of experimentally-induced pain was used.<h4>M...

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Autores principales:	Helen Vossen, Gunter Kenis, Bart Rutten, Jim van Os, Hermie Hermens, Richel Lousberg
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/513e2eb67fbb44588dbedf2b6192ea11
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spelling	oai:doaj.org-article:513e2eb67fbb44588dbedf2b6192ea112021-11-18T07:02:51ZThe genetic influence on the cortical processing of experimental pain and the moderating effect of pain status.1932-620310.1371/journal.pone.0013641https://doaj.org/article/513e2eb67fbb44588dbedf2b6192ea112010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21049025/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Research suggests that the COMT Val(158)Met, BDNF Val(66)Met and OPRM1 A(118)G polymorphisms moderate the experience of pain. In order to obtain experimental confirmation and extension of findings, cortical processing of experimentally-induced pain was used.<h4>Method</h4>A sample of 78 individuals with chronic low back pain complaints and 37 healthy controls underwent EEG registration. Event-Related Potentials were measured in response to electrical nociceptive stimuli and moderation by COMT Val(158)Met, BDNF Val(66)Met and OPRM1 A(118)G polymorphisms was assessed.<h4>Results</h4>Genetic variation did not have a direct effect on cortical processing of experimental pain. However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain. In the presence of chronic pain, the COMT Met allele and the BDNF Met allele augmented cortical pain processing, whilst reducing pain processing in pain-free controls. No significant effects were found concerning the OPRM1 A(118)G polymorphism.<h4>Conclusions</h4>The current study suggests that chronic experience of pain enhances genetic sensitivity to experimentally induced mildly painful stimuli, possibly through a process of epigenetic modification.Helen VossenGunter KenisBart RuttenJim van OsHermie HermensRichel LousbergPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10, p e13641 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Helen Vossen Gunter Kenis Bart Rutten Jim van Os Hermie Hermens Richel Lousberg The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status.
description	<h4>Background</h4>Research suggests that the COMT Val(158)Met, BDNF Val(66)Met and OPRM1 A(118)G polymorphisms moderate the experience of pain. In order to obtain experimental confirmation and extension of findings, cortical processing of experimentally-induced pain was used.<h4>Method</h4>A sample of 78 individuals with chronic low back pain complaints and 37 healthy controls underwent EEG registration. Event-Related Potentials were measured in response to electrical nociceptive stimuli and moderation by COMT Val(158)Met, BDNF Val(66)Met and OPRM1 A(118)G polymorphisms was assessed.<h4>Results</h4>Genetic variation did not have a direct effect on cortical processing of experimental pain. However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain. In the presence of chronic pain, the COMT Met allele and the BDNF Met allele augmented cortical pain processing, whilst reducing pain processing in pain-free controls. No significant effects were found concerning the OPRM1 A(118)G polymorphism.<h4>Conclusions</h4>The current study suggests that chronic experience of pain enhances genetic sensitivity to experimentally induced mildly painful stimuli, possibly through a process of epigenetic modification.
format	article
author	Helen Vossen Gunter Kenis Bart Rutten Jim van Os Hermie Hermens Richel Lousberg
author_facet	Helen Vossen Gunter Kenis Bart Rutten Jim van Os Hermie Hermens Richel Lousberg
author_sort	Helen Vossen
title	The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status.
title_short	The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status.
title_full	The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status.
title_fullStr	The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status.
title_full_unstemmed	The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status.
title_sort	genetic influence on the cortical processing of experimental pain and the moderating effect of pain status.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/513e2eb67fbb44588dbedf2b6192ea11
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The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status.

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