Induced Pluripotent Stem Cells as a Tool for Modeling Hematologic Disorders and as a Potential Source for Cell-Based Therapies

The breakthrough in human induced pluripotent stem cells (hiPSCs) has revolutionized the field of biomedical and pharmaceutical research and opened up vast opportunities for drug discovery and regenerative medicine, especially when combined with gene-editing technology. Numerous healthy and patient-...

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Autores principales:	Ponthip Pratumkaew, Surapol Issaragrisil, Sudjit Luanpitpong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	induced pluripotent stem cells disease modeling blood disorders genetic disorders cell-based therapy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/513f4ba059c8477181c91919750b619f
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spelling	oai:doaj.org-article:513f4ba059c8477181c91919750b619f2021-11-25T17:13:17ZInduced Pluripotent Stem Cells as a Tool for Modeling Hematologic Disorders and as a Potential Source for Cell-Based Therapies10.3390/cells101132502073-4409https://doaj.org/article/513f4ba059c8477181c91919750b619f2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3250https://doaj.org/toc/2073-4409The breakthrough in human induced pluripotent stem cells (hiPSCs) has revolutionized the field of biomedical and pharmaceutical research and opened up vast opportunities for drug discovery and regenerative medicine, especially when combined with gene-editing technology. Numerous healthy and patient-derived hiPSCs for human disease modeling have been established, enabling mechanistic studies of pathogenesis, platforms for preclinical drug screening, and the development of novel therapeutic targets/approaches. Additionally, hiPSCs hold great promise for cell-based therapy, serving as an attractive cell source for generating stem/progenitor cells or functional differentiated cells for degenerative diseases, due to their unlimited proliferative capacity, pluripotency, and ethical acceptability. In this review, we provide an overview of hiPSCs and their utility in the study of hematologic disorders through hematopoietic differentiation. We highlight recent hereditary and acquired genetic hematologic disease modeling with patient-specific iPSCs, and discuss their applications as instrumental drug screening tools. The clinical applications of hiPSCs in cell-based therapy, including the next-generation cancer immunotherapy, are provided. Lastly, we discuss the current challenges that need to be addressed to fulfill the validity of hiPSC-based disease modeling and future perspectives of hiPSCs in the field of hematology.Ponthip PratumkaewSurapol IssaragrisilSudjit LuanpitpongMDPI AGarticleinduced pluripotent stem cellsdisease modelingblood disordersgenetic disorderscell-based therapyBiology (General)QH301-705.5ENCells, Vol 10, Iss 3250, p 3250 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	induced pluripotent stem cells disease modeling blood disorders genetic disorders cell-based therapy Biology (General) QH301-705.5
spellingShingle	induced pluripotent stem cells disease modeling blood disorders genetic disorders cell-based therapy Biology (General) QH301-705.5 Ponthip Pratumkaew Surapol Issaragrisil Sudjit Luanpitpong Induced Pluripotent Stem Cells as a Tool for Modeling Hematologic Disorders and as a Potential Source for Cell-Based Therapies
description	The breakthrough in human induced pluripotent stem cells (hiPSCs) has revolutionized the field of biomedical and pharmaceutical research and opened up vast opportunities for drug discovery and regenerative medicine, especially when combined with gene-editing technology. Numerous healthy and patient-derived hiPSCs for human disease modeling have been established, enabling mechanistic studies of pathogenesis, platforms for preclinical drug screening, and the development of novel therapeutic targets/approaches. Additionally, hiPSCs hold great promise for cell-based therapy, serving as an attractive cell source for generating stem/progenitor cells or functional differentiated cells for degenerative diseases, due to their unlimited proliferative capacity, pluripotency, and ethical acceptability. In this review, we provide an overview of hiPSCs and their utility in the study of hematologic disorders through hematopoietic differentiation. We highlight recent hereditary and acquired genetic hematologic disease modeling with patient-specific iPSCs, and discuss their applications as instrumental drug screening tools. The clinical applications of hiPSCs in cell-based therapy, including the next-generation cancer immunotherapy, are provided. Lastly, we discuss the current challenges that need to be addressed to fulfill the validity of hiPSC-based disease modeling and future perspectives of hiPSCs in the field of hematology.
format	article
author	Ponthip Pratumkaew Surapol Issaragrisil Sudjit Luanpitpong
author_facet	Ponthip Pratumkaew Surapol Issaragrisil Sudjit Luanpitpong
author_sort	Ponthip Pratumkaew
title	Induced Pluripotent Stem Cells as a Tool for Modeling Hematologic Disorders and as a Potential Source for Cell-Based Therapies
title_short	Induced Pluripotent Stem Cells as a Tool for Modeling Hematologic Disorders and as a Potential Source for Cell-Based Therapies
title_full	Induced Pluripotent Stem Cells as a Tool for Modeling Hematologic Disorders and as a Potential Source for Cell-Based Therapies
title_fullStr	Induced Pluripotent Stem Cells as a Tool for Modeling Hematologic Disorders and as a Potential Source for Cell-Based Therapies
title_full_unstemmed	Induced Pluripotent Stem Cells as a Tool for Modeling Hematologic Disorders and as a Potential Source for Cell-Based Therapies
title_sort	induced pluripotent stem cells as a tool for modeling hematologic disorders and as a potential source for cell-based therapies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/513f4ba059c8477181c91919750b619f
work_keys_str_mv	AT ponthippratumkaew inducedpluripotentstemcellsasatoolformodelinghematologicdisordersandasapotentialsourceforcellbasedtherapies AT surapolissaragrisil inducedpluripotentstemcellsasatoolformodelinghematologicdisordersandasapotentialsourceforcellbasedtherapies AT sudjitluanpitpong inducedpluripotentstemcellsasatoolformodelinghematologicdisordersandasapotentialsourceforcellbasedtherapies
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Induced Pluripotent Stem Cells as a Tool for Modeling Hematologic Disorders and as a Potential Source for Cell-Based Therapies

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