Low bone turnover is associated with plain X-ray vascular calcification in predialysis patients.

<h4>Background</h4>Vascular calcification (VC) is a common finding in chronic kidney disease (CKD) patients and predicts subsequent cardiovascular morbidity and mortality in this population. Vascular calcification is linked to disordered mineral metabolism and has been associated with bo...

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Autores principales:	Ricardo Neto, Luciano Pereira, Juliana Magalhães, Janete Quelhas-Santos, João Frazão
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/51417393e0164df3ba9acd52a22f2e85
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spelling	oai:doaj.org-article:51417393e0164df3ba9acd52a22f2e852021-12-02T20:13:42ZLow bone turnover is associated with plain X-ray vascular calcification in predialysis patients.1932-620310.1371/journal.pone.0258284https://doaj.org/article/51417393e0164df3ba9acd52a22f2e852021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258284https://doaj.org/toc/1932-6203<h4>Background</h4>Vascular calcification (VC) is a common finding in chronic kidney disease (CKD) patients and predicts subsequent cardiovascular morbidity and mortality in this population. Vascular calcification is linked to disordered mineral metabolism and has been associated with bone histomorphometry changes in CKD. However, data on predialysis patients is scarce.<h4>Methods</h4>A cross-sectional study was conducted on a cohort of 56 CKD patients not yet on dialysis, who underwent a transiliac bone biopsy for histomorphometric evaluation after double tetracycline labeling. Patients had no previous exposure to calcium salts, vitamin D agents, steroids or bisphosphonates. Vascular calcification was assessed at the time of biopsy, using Kauppila (plain X-ray of the lateral lumbar spine) and Adragão (plain X-ray of the pelvis and hands) scores.<h4>Results</h4>Vascular calcification was seen in two-thirds of the cohort. Subjects with VC were more likely to be male and have diabetes, and had significantly higher sclerostin and osteoprotegerin circulating levels than those without VC. The histomorphometric analysis showed that bone formation rate was significantly lower in VC compared to non-VC patients. In the multivariable logistic regression analysis, bone formation rate was independently associated with the presence of VC.<h4>Conclusions</h4>Vascular calcification is highly prevalent in predialysis patients, especially in those with diabetes. The independent association between bone formation rate and VC provides evidence of an important interaction between bone and vessel in CKD. Our results suggest that low bone turnover is a non-traditional risk factor for cardiovascular disease in predialysis patients.Ricardo NetoLuciano PereiraJuliana MagalhãesJanete Quelhas-SantosJoão FrazãoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258284 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ricardo Neto Luciano Pereira Juliana Magalhães Janete Quelhas-Santos João Frazão Low bone turnover is associated with plain X-ray vascular calcification in predialysis patients.
description	<h4>Background</h4>Vascular calcification (VC) is a common finding in chronic kidney disease (CKD) patients and predicts subsequent cardiovascular morbidity and mortality in this population. Vascular calcification is linked to disordered mineral metabolism and has been associated with bone histomorphometry changes in CKD. However, data on predialysis patients is scarce.<h4>Methods</h4>A cross-sectional study was conducted on a cohort of 56 CKD patients not yet on dialysis, who underwent a transiliac bone biopsy for histomorphometric evaluation after double tetracycline labeling. Patients had no previous exposure to calcium salts, vitamin D agents, steroids or bisphosphonates. Vascular calcification was assessed at the time of biopsy, using Kauppila (plain X-ray of the lateral lumbar spine) and Adragão (plain X-ray of the pelvis and hands) scores.<h4>Results</h4>Vascular calcification was seen in two-thirds of the cohort. Subjects with VC were more likely to be male and have diabetes, and had significantly higher sclerostin and osteoprotegerin circulating levels than those without VC. The histomorphometric analysis showed that bone formation rate was significantly lower in VC compared to non-VC patients. In the multivariable logistic regression analysis, bone formation rate was independently associated with the presence of VC.<h4>Conclusions</h4>Vascular calcification is highly prevalent in predialysis patients, especially in those with diabetes. The independent association between bone formation rate and VC provides evidence of an important interaction between bone and vessel in CKD. Our results suggest that low bone turnover is a non-traditional risk factor for cardiovascular disease in predialysis patients.
format	article
author	Ricardo Neto Luciano Pereira Juliana Magalhães Janete Quelhas-Santos João Frazão
author_facet	Ricardo Neto Luciano Pereira Juliana Magalhães Janete Quelhas-Santos João Frazão
author_sort	Ricardo Neto
title	Low bone turnover is associated with plain X-ray vascular calcification in predialysis patients.
title_short	Low bone turnover is associated with plain X-ray vascular calcification in predialysis patients.
title_full	Low bone turnover is associated with plain X-ray vascular calcification in predialysis patients.
title_fullStr	Low bone turnover is associated with plain X-ray vascular calcification in predialysis patients.
title_full_unstemmed	Low bone turnover is associated with plain X-ray vascular calcification in predialysis patients.
title_sort	low bone turnover is associated with plain x-ray vascular calcification in predialysis patients.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/51417393e0164df3ba9acd52a22f2e85
work_keys_str_mv	AT ricardoneto lowboneturnoverisassociatedwithplainxrayvascularcalcificationinpredialysispatients AT lucianopereira lowboneturnoverisassociatedwithplainxrayvascularcalcificationinpredialysispatients AT julianamagalhaes lowboneturnoverisassociatedwithplainxrayvascularcalcificationinpredialysispatients AT janetequelhassantos lowboneturnoverisassociatedwithplainxrayvascularcalcificationinpredialysispatients AT joaofrazao lowboneturnoverisassociatedwithplainxrayvascularcalcificationinpredialysispatients
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Low bone turnover is associated with plain X-ray vascular calcification in predialysis patients.

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