The Correlations between Cord Blood Leptin and Leptin Level at Six Months with Infant Growth

Background: Leptin plays an important role in regulating body weight, metabolism, and reproductive functions. Leptin affects metabolism by reducing nutrient intake and increasing energy expenditure which eventually also plays a role in infant growth. Objective: This study aims to determine the rela...

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Autores principales:	Ika Rara Rosita, Agustini Utari, Maria Mexitalia
Formato:	article
Lenguaje:	EN
Publicado:	Diponegoro University 2021
Materias:	leptin cord blood leptin infant growth Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/51423c07af0f401abf63b8adf886b6ca
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spelling	oai:doaj.org-article:51423c07af0f401abf63b8adf886b6ca2021-11-05T16:47:51ZThe Correlations between Cord Blood Leptin and Leptin Level at Six Months with Infant Growth2503-217810.14710/jbtr.v7i2.11821https://doaj.org/article/51423c07af0f401abf63b8adf886b6ca2021-08-01T00:00:00Zhttps://ejournal2.undip.ac.id/index.php/jbtr/article/view/11821https://doaj.org/toc/2503-2178Background: Leptin plays an important role in regulating body weight, metabolism, and reproductive functions. Leptin affects metabolism by reducing nutrient intake and increasing energy expenditure which eventually also plays a role in infant growth. Objective: This study aims to determine the relationship between leptin levels and infant growth age 0-6 months. Methods: A prospective cohort study was done for six months on 38 infants, age 0-6 months, from breastfeeding mothers with normal pregnancies. The samples were taken twice, firstly when the infant was born using an umbilical cord blood sample, and secondly at the age of six months, using a vein blood sample. Serum leptin levels were measured using the ELISA method. Infant growth was assessed using WHO 2005’s z-scores. Results: A total of 50 babies were included in the study, 38 of them had been studied completely. Significant correlations were found between the mean of the umbilical cord and six months of age leptin levels (p <0.001), between delta leptin with WHZ and delta leptin with WAZ at six months of age (p = 0.002 and p = 0.003, respectively), and between leptin levels with WHZ (p<0.001) and leptin levels with WAZ (p = 0.004) at six months of age. Leptin levels at the age of six months are lower than umbilical cord blood leptin. Conclusion: The greater decrease of leptin level in the first six months is associated with better infant growth.Ika Rara RositaAgustini UtariMaria MexitaliaDiponegoro Universityarticleleptincord blood leptininfant growthMedicine (General)R5-920ENJournal of Biomedicine and Translational Research, Vol 7, Iss 2, Pp 74-78 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	leptin cord blood leptin infant growth Medicine (General) R5-920
spellingShingle	leptin cord blood leptin infant growth Medicine (General) R5-920 Ika Rara Rosita Agustini Utari Maria Mexitalia The Correlations between Cord Blood Leptin and Leptin Level at Six Months with Infant Growth
description	Background: Leptin plays an important role in regulating body weight, metabolism, and reproductive functions. Leptin affects metabolism by reducing nutrient intake and increasing energy expenditure which eventually also plays a role in infant growth. Objective: This study aims to determine the relationship between leptin levels and infant growth age 0-6 months. Methods: A prospective cohort study was done for six months on 38 infants, age 0-6 months, from breastfeeding mothers with normal pregnancies. The samples were taken twice, firstly when the infant was born using an umbilical cord blood sample, and secondly at the age of six months, using a vein blood sample. Serum leptin levels were measured using the ELISA method. Infant growth was assessed using WHO 2005’s z-scores. Results: A total of 50 babies were included in the study, 38 of them had been studied completely. Significant correlations were found between the mean of the umbilical cord and six months of age leptin levels (p <0.001), between delta leptin with WHZ and delta leptin with WAZ at six months of age (p = 0.002 and p = 0.003, respectively), and between leptin levels with WHZ (p<0.001) and leptin levels with WAZ (p = 0.004) at six months of age. Leptin levels at the age of six months are lower than umbilical cord blood leptin. Conclusion: The greater decrease of leptin level in the first six months is associated with better infant growth.
format	article
author	Ika Rara Rosita Agustini Utari Maria Mexitalia
author_facet	Ika Rara Rosita Agustini Utari Maria Mexitalia
author_sort	Ika Rara Rosita
title	The Correlations between Cord Blood Leptin and Leptin Level at Six Months with Infant Growth
title_short	The Correlations between Cord Blood Leptin and Leptin Level at Six Months with Infant Growth
title_full	The Correlations between Cord Blood Leptin and Leptin Level at Six Months with Infant Growth
title_fullStr	The Correlations between Cord Blood Leptin and Leptin Level at Six Months with Infant Growth
title_full_unstemmed	The Correlations between Cord Blood Leptin and Leptin Level at Six Months with Infant Growth
title_sort	correlations between cord blood leptin and leptin level at six months with infant growth
publisher	Diponegoro University
publishDate	2021
url	https://doaj.org/article/51423c07af0f401abf63b8adf886b6ca
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The Correlations between Cord Blood Leptin and Leptin Level at Six Months with Infant Growth

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