A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma

Neuroblastoma includes adrenergic and mesenchymal cell types that can interconvert. Here, the authors show that this transdifferentiation is driven by a NOTCH feedforward loop that allows a swift transition between two semi-stable cellular states.

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Autores principales:	Tim van Groningen, Nurdan Akogul, Ellen M. Westerhout, Alvin Chan, Nancy E. Hasselt, Danny A. Zwijnenburg, Marloes Broekmans, Peter Stroeken, Franciska Haneveld, Gerrit K. J. Hooijer, C. Dilara Savci-Heijink, Arjan Lakeman, Richard Volckmann, Peter van Sluis, Linda J. Valentijn, Jan Koster, Rogier Versteeg, Johan van Nes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/514276fb271e42e0afc3df43c40d7742
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spelling	oai:doaj.org-article:514276fb271e42e0afc3df43c40d77422021-12-02T17:01:50ZA NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma10.1038/s41467-019-09470-w2041-1723https://doaj.org/article/514276fb271e42e0afc3df43c40d77422019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09470-whttps://doaj.org/toc/2041-1723Neuroblastoma includes adrenergic and mesenchymal cell types that can interconvert. Here, the authors show that this transdifferentiation is driven by a NOTCH feedforward loop that allows a swift transition between two semi-stable cellular states.Tim van GroningenNurdan AkogulEllen M. WesterhoutAlvin ChanNancy E. HasseltDanny A. ZwijnenburgMarloes BroekmansPeter StroekenFranciska HaneveldGerrit K. J. HooijerC. Dilara Savci-HeijinkArjan LakemanRichard VolckmannPeter van SluisLinda J. ValentijnJan KosterRogier VersteegJohan van NesNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tim van Groningen Nurdan Akogul Ellen M. Westerhout Alvin Chan Nancy E. Hasselt Danny A. Zwijnenburg Marloes Broekmans Peter Stroeken Franciska Haneveld Gerrit K. J. Hooijer C. Dilara Savci-Heijink Arjan Lakeman Richard Volckmann Peter van Sluis Linda J. Valentijn Jan Koster Rogier Versteeg Johan van Nes A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
description	Neuroblastoma includes adrenergic and mesenchymal cell types that can interconvert. Here, the authors show that this transdifferentiation is driven by a NOTCH feedforward loop that allows a swift transition between two semi-stable cellular states.
format	article
author	Tim van Groningen Nurdan Akogul Ellen M. Westerhout Alvin Chan Nancy E. Hasselt Danny A. Zwijnenburg Marloes Broekmans Peter Stroeken Franciska Haneveld Gerrit K. J. Hooijer C. Dilara Savci-Heijink Arjan Lakeman Richard Volckmann Peter van Sluis Linda J. Valentijn Jan Koster Rogier Versteeg Johan van Nes
author_facet	Tim van Groningen Nurdan Akogul Ellen M. Westerhout Alvin Chan Nancy E. Hasselt Danny A. Zwijnenburg Marloes Broekmans Peter Stroeken Franciska Haneveld Gerrit K. J. Hooijer C. Dilara Savci-Heijink Arjan Lakeman Richard Volckmann Peter van Sluis Linda J. Valentijn Jan Koster Rogier Versteeg Johan van Nes
author_sort	Tim van Groningen
title	A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
title_short	A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
title_full	A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
title_fullStr	A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
title_full_unstemmed	A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
title_sort	notch feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/514276fb271e42e0afc3df43c40d7742
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_version_	1718382028382011392

A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma

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