Operant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice

Abstract Altered functioning of GABAergic interneurons expressing parvalbumin (PV) in the basal ganglia-thalamo-cortical circuit are likely to be involved in several human psychiatric disorders characterized by deficits in attention and sensory gating with dysfunctional decision-making behavior. How...

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Autores principales:	Alessandra Lintas, Raudel Sánchez-Campusano, Alessandro E. P. Villa, Agnès Gruart, José M. Delgado-García
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5143ea5939784d48a1bf7ff4ff4d9d28
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spelling	oai:doaj.org-article:5143ea5939784d48a1bf7ff4ff4d9d282021-12-02T14:06:51ZOperant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice10.1038/s41598-021-82519-32045-2322https://doaj.org/article/5143ea5939784d48a1bf7ff4ff4d9d282021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82519-3https://doaj.org/toc/2045-2322Abstract Altered functioning of GABAergic interneurons expressing parvalbumin (PV) in the basal ganglia-thalamo-cortical circuit are likely to be involved in several human psychiatric disorders characterized by deficits in attention and sensory gating with dysfunctional decision-making behavior. However, the contribution of these interneurons in the ability to acquire demanding learning tasks remains unclear. Here, we combine an operant conditioning task with local field potentials simultaneously recorded in several nuclei involved in reward circuits of wild-type (WT) and PV-deficient (PVKO) mice, which are characterized by changes in firing activity of PV-expressing interneurons. In comparison with WT mice, PVKO animals presented significant deficits in the acquisition of the selected learning task. Recordings from prefrontal cortex, nucleus accumbens (NAc) and hippocampus showed significant decreases of the spectral power in beta and gamma bands in PVKO compared with WT mice particularly during the performance of the operant conditioning task. From the first to the last session, at all frequency bands the spectral power in NAc tended to increase in WT and to decrease in PVKO. Results indicate that PV deficiency impairs signaling necessary for instrumental learning and the recognition of natural rewards.Alessandra LintasRaudel Sánchez-CampusanoAlessandro E. P. VillaAgnès GruartJosé M. Delgado-GarcíaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alessandra Lintas Raudel Sánchez-Campusano Alessandro E. P. Villa Agnès Gruart José M. Delgado-García Operant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice
description	Abstract Altered functioning of GABAergic interneurons expressing parvalbumin (PV) in the basal ganglia-thalamo-cortical circuit are likely to be involved in several human psychiatric disorders characterized by deficits in attention and sensory gating with dysfunctional decision-making behavior. However, the contribution of these interneurons in the ability to acquire demanding learning tasks remains unclear. Here, we combine an operant conditioning task with local field potentials simultaneously recorded in several nuclei involved in reward circuits of wild-type (WT) and PV-deficient (PVKO) mice, which are characterized by changes in firing activity of PV-expressing interneurons. In comparison with WT mice, PVKO animals presented significant deficits in the acquisition of the selected learning task. Recordings from prefrontal cortex, nucleus accumbens (NAc) and hippocampus showed significant decreases of the spectral power in beta and gamma bands in PVKO compared with WT mice particularly during the performance of the operant conditioning task. From the first to the last session, at all frequency bands the spectral power in NAc tended to increase in WT and to decrease in PVKO. Results indicate that PV deficiency impairs signaling necessary for instrumental learning and the recognition of natural rewards.
format	article
author	Alessandra Lintas Raudel Sánchez-Campusano Alessandro E. P. Villa Agnès Gruart José M. Delgado-García
author_facet	Alessandra Lintas Raudel Sánchez-Campusano Alessandro E. P. Villa Agnès Gruart José M. Delgado-García
author_sort	Alessandra Lintas
title	Operant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice
title_short	Operant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice
title_full	Operant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice
title_fullStr	Operant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice
title_full_unstemmed	Operant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice
title_sort	operant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5143ea5939784d48a1bf7ff4ff4d9d28
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Operant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice

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