A comprehensive comparison between camelid nanobodies and single chain variable fragments

Abstract By the emergence of recombinant DNA technology, many antibody fragments have been developed devoid of undesired properties of natural immunoglobulins. Among them, camelid heavy-chain variable domains (VHHs) and single-chain variable fragments (scFvs) are the most favored ones. While scFv is...

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Autores principales:	Yasaman Asaadi, Fatemeh Fazlollahi Jouneghani, Sara Janani, Fatemeh Rahbarizadeh
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Single-chain variable fragment (scFv) camelid VHH nanobody single-domain antibody Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/51458c53b6ff42df89fdb9ce86ae855e
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spelling	oai:doaj.org-article:51458c53b6ff42df89fdb9ce86ae855e2021-12-05T12:07:04ZA comprehensive comparison between camelid nanobodies and single chain variable fragments10.1186/s40364-021-00332-62050-7771https://doaj.org/article/51458c53b6ff42df89fdb9ce86ae855e2021-12-01T00:00:00Zhttps://doi.org/10.1186/s40364-021-00332-6https://doaj.org/toc/2050-7771Abstract By the emergence of recombinant DNA technology, many antibody fragments have been developed devoid of undesired properties of natural immunoglobulins. Among them, camelid heavy-chain variable domains (VHHs) and single-chain variable fragments (scFvs) are the most favored ones. While scFv is used widely in various applications, camelid antibodies (VHHs) can serve as an alternative because of their superior chemical and physical properties such as higher solubility, stability, smaller size, and lower production cost. Here, these two counterparts are compared in structure and properties to identify which one is more suitable for each of their various therapeutic, diagnosis, and research applications.Yasaman AsaadiFatemeh Fazlollahi JouneghaniSara JananiFatemeh RahbarizadehBMCarticleSingle-chain variable fragment (scFv)camelid VHHnanobodysingle-domain antibodyTherapeutics. PharmacologyRM1-950ENBiomarker Research, Vol 9, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Single-chain variable fragment (scFv) camelid VHH nanobody single-domain antibody Therapeutics. Pharmacology RM1-950
spellingShingle	Single-chain variable fragment (scFv) camelid VHH nanobody single-domain antibody Therapeutics. Pharmacology RM1-950 Yasaman Asaadi Fatemeh Fazlollahi Jouneghani Sara Janani Fatemeh Rahbarizadeh A comprehensive comparison between camelid nanobodies and single chain variable fragments
description	Abstract By the emergence of recombinant DNA technology, many antibody fragments have been developed devoid of undesired properties of natural immunoglobulins. Among them, camelid heavy-chain variable domains (VHHs) and single-chain variable fragments (scFvs) are the most favored ones. While scFv is used widely in various applications, camelid antibodies (VHHs) can serve as an alternative because of their superior chemical and physical properties such as higher solubility, stability, smaller size, and lower production cost. Here, these two counterparts are compared in structure and properties to identify which one is more suitable for each of their various therapeutic, diagnosis, and research applications.
format	article
author	Yasaman Asaadi Fatemeh Fazlollahi Jouneghani Sara Janani Fatemeh Rahbarizadeh
author_facet	Yasaman Asaadi Fatemeh Fazlollahi Jouneghani Sara Janani Fatemeh Rahbarizadeh
author_sort	Yasaman Asaadi
title	A comprehensive comparison between camelid nanobodies and single chain variable fragments
title_short	A comprehensive comparison between camelid nanobodies and single chain variable fragments
title_full	A comprehensive comparison between camelid nanobodies and single chain variable fragments
title_fullStr	A comprehensive comparison between camelid nanobodies and single chain variable fragments
title_full_unstemmed	A comprehensive comparison between camelid nanobodies and single chain variable fragments
title_sort	comprehensive comparison between camelid nanobodies and single chain variable fragments
publisher	BMC
publishDate	2021
url	https://doaj.org/article/51458c53b6ff42df89fdb9ce86ae855e
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A comprehensive comparison between camelid nanobodies and single chain variable fragments

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