Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice

Immunotherapy for the treatment of cancer can be complicated by side effects and poor efficacy. Here, the authors use a nanoparticle-based approach in combination with a TLR7 agonist and sonodynamic therapy, and find that when used together with anti-PD-L1, tumour formation and metastases are impact...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wenwen Yue, Liang Chen, Luodan Yu, Bangguo Zhou, Haohao Yin, Weiwei Ren, Chang Liu, Lehang Guo, Yifeng Zhang, Liping Sun, Kun Zhang, Huixiong Xu, Yu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/514612188b274ea7bd139a20fa716512
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:514612188b274ea7bd139a20fa716512
record_format	dspace
spelling	oai:doaj.org-article:514612188b274ea7bd139a20fa7165122021-12-02T16:58:03ZCheckpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice10.1038/s41467-019-09760-32041-1723https://doaj.org/article/514612188b274ea7bd139a20fa7165122019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09760-3https://doaj.org/toc/2041-1723Immunotherapy for the treatment of cancer can be complicated by side effects and poor efficacy. Here, the authors use a nanoparticle-based approach in combination with a TLR7 agonist and sonodynamic therapy, and find that when used together with anti-PD-L1, tumour formation and metastases are impacted.Wenwen YueLiang ChenLuodan YuBangguo ZhouHaohao YinWeiwei RenChang LiuLehang GuoYifeng ZhangLiping SunKun ZhangHuixiong XuYu ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenwen Yue Liang Chen Luodan Yu Bangguo Zhou Haohao Yin Weiwei Ren Chang Liu Lehang Guo Yifeng Zhang Liping Sun Kun Zhang Huixiong Xu Yu Chen Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
description	Immunotherapy for the treatment of cancer can be complicated by side effects and poor efficacy. Here, the authors use a nanoparticle-based approach in combination with a TLR7 agonist and sonodynamic therapy, and find that when used together with anti-PD-L1, tumour formation and metastases are impacted.
format	article
author	Wenwen Yue Liang Chen Luodan Yu Bangguo Zhou Haohao Yin Weiwei Ren Chang Liu Lehang Guo Yifeng Zhang Liping Sun Kun Zhang Huixiong Xu Yu Chen
author_facet	Wenwen Yue Liang Chen Luodan Yu Bangguo Zhou Haohao Yin Weiwei Ren Chang Liu Lehang Guo Yifeng Zhang Liping Sun Kun Zhang Huixiong Xu Yu Chen
author_sort	Wenwen Yue
title	Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
title_short	Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
title_full	Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
title_fullStr	Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
title_full_unstemmed	Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
title_sort	checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/514612188b274ea7bd139a20fa716512
work_keys_str_mv	AT wenwenyue checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice AT liangchen checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice AT luodanyu checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice AT bangguozhou checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice AT haohaoyin checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice AT weiweiren checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice AT changliu checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice AT lehangguo checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice AT yifengzhang checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice AT lipingsun checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice AT kunzhang checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice AT huixiongxu checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice AT yuchen checkpointblockadeandnanosonosensitizeraugmentednoninvasivesonodynamictherapycombinationreducestumourgrowthandmetastasesinmice
_version_	1718382384581181440

Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice

Ejemplares similares