Association between Osteoporosis and Previous Statin Use: A Nested Case-Control Study

The relationship between statin use and osteoporosis is controversial; therefore, this study aimed to investigate this association. The ≥40-year-old population of the Korean National Health Insurance Service Health Screening Cohort was enrolled. The 68,592 osteoporosis patients were matched 1:1 with...

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Autores principales:	So Young Kim, Dae Myoung Yoo, Chanyang Min, Ji Hee Kim, Mi Jung Kwon, Joo-Hee Kim, Hyo Geun Choi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	osteoporosis hydroxymethylglutaryl-CoA reductase inhibitors risk factors cohort studies Medicine R
Acceso en línea:	https://doaj.org/article/51473e54314e408aba57f66b55eb3ab9
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id	oai:doaj.org-article:51473e54314e408aba57f66b55eb3ab9
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spelling	oai:doaj.org-article:51473e54314e408aba57f66b55eb3ab92021-11-25T17:49:19ZAssociation between Osteoporosis and Previous Statin Use: A Nested Case-Control Study10.3390/ijerph1822119021660-46011661-7827https://doaj.org/article/51473e54314e408aba57f66b55eb3ab92021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/11902https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601The relationship between statin use and osteoporosis is controversial; therefore, this study aimed to investigate this association. The ≥40-year-old population of the Korean National Health Insurance Service Health Screening Cohort was enrolled. The 68,592 osteoporosis patients were matched 1:1 with control participants for age, sex, income, and region of residence using propensity score matching. The histories of statin use for two years before the diagnosis of osteoporosis (index date) in the osteoporosis and control groups were compared using conditional/unconditional logistic regression. An increased number of days of statin use was not associated with osteoporosis (adjusted OR (aOR) = 0.97, 95% confidence interval (95% CI) = 0.94–1.00, <i>p</i> = 0.052). In the subgroup analyses, a large number of days of statin use was related to a reduced rate of osteoporosis in the <60-year-old female group, while the opposite was true in the ≥60-year-old female group. Both lipophilic and hydrophilic statins were related to a decreased rate of osteoporosis in the <60-year-old female group. Lipophilic statins, but not hydrophilic statins, were associated with an increased rate of osteoporosis in the ≥60-year-old female group. Statin use showed different associations in middle-aged and elderly women.So Young KimDae Myoung YooChanyang MinJi Hee KimMi Jung KwonJoo-Hee KimHyo Geun ChoiMDPI AGarticleosteoporosishydroxymethylglutaryl-CoA reductase inhibitorsrisk factorscohort studiesMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11902, p 11902 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoporosis hydroxymethylglutaryl-CoA reductase inhibitors risk factors cohort studies Medicine R
spellingShingle	osteoporosis hydroxymethylglutaryl-CoA reductase inhibitors risk factors cohort studies Medicine R So Young Kim Dae Myoung Yoo Chanyang Min Ji Hee Kim Mi Jung Kwon Joo-Hee Kim Hyo Geun Choi Association between Osteoporosis and Previous Statin Use: A Nested Case-Control Study
description	The relationship between statin use and osteoporosis is controversial; therefore, this study aimed to investigate this association. The ≥40-year-old population of the Korean National Health Insurance Service Health Screening Cohort was enrolled. The 68,592 osteoporosis patients were matched 1:1 with control participants for age, sex, income, and region of residence using propensity score matching. The histories of statin use for two years before the diagnosis of osteoporosis (index date) in the osteoporosis and control groups were compared using conditional/unconditional logistic regression. An increased number of days of statin use was not associated with osteoporosis (adjusted OR (aOR) = 0.97, 95% confidence interval (95% CI) = 0.94–1.00, <i>p</i> = 0.052). In the subgroup analyses, a large number of days of statin use was related to a reduced rate of osteoporosis in the <60-year-old female group, while the opposite was true in the ≥60-year-old female group. Both lipophilic and hydrophilic statins were related to a decreased rate of osteoporosis in the <60-year-old female group. Lipophilic statins, but not hydrophilic statins, were associated with an increased rate of osteoporosis in the ≥60-year-old female group. Statin use showed different associations in middle-aged and elderly women.
format	article
author	So Young Kim Dae Myoung Yoo Chanyang Min Ji Hee Kim Mi Jung Kwon Joo-Hee Kim Hyo Geun Choi
author_facet	So Young Kim Dae Myoung Yoo Chanyang Min Ji Hee Kim Mi Jung Kwon Joo-Hee Kim Hyo Geun Choi
author_sort	So Young Kim
title	Association between Osteoporosis and Previous Statin Use: A Nested Case-Control Study
title_short	Association between Osteoporosis and Previous Statin Use: A Nested Case-Control Study
title_full	Association between Osteoporosis and Previous Statin Use: A Nested Case-Control Study
title_fullStr	Association between Osteoporosis and Previous Statin Use: A Nested Case-Control Study
title_full_unstemmed	Association between Osteoporosis and Previous Statin Use: A Nested Case-Control Study
title_sort	association between osteoporosis and previous statin use: a nested case-control study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/51473e54314e408aba57f66b55eb3ab9
work_keys_str_mv	AT soyoungkim associationbetweenosteoporosisandpreviousstatinuseanestedcasecontrolstudy AT daemyoungyoo associationbetweenosteoporosisandpreviousstatinuseanestedcasecontrolstudy AT chanyangmin associationbetweenosteoporosisandpreviousstatinuseanestedcasecontrolstudy AT jiheekim associationbetweenosteoporosisandpreviousstatinuseanestedcasecontrolstudy AT mijungkwon associationbetweenosteoporosisandpreviousstatinuseanestedcasecontrolstudy AT jooheekim associationbetweenosteoporosisandpreviousstatinuseanestedcasecontrolstudy AT hyogeunchoi associationbetweenosteoporosisandpreviousstatinuseanestedcasecontrolstudy
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Association between Osteoporosis and Previous Statin Use: A Nested Case-Control Study

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