Glycogen metabolism regulates macrophage-mediated acute inflammatory responses

Glycogen metabolism regulates macrophage-mediated acute inflammatory responses

Glycogen can be metabolized via glycogenolysis and the pentose phosphate pathway as well as into the production of UDP glucose, which when secreted can bind the P2Y14 receptor. Here the authors show how these glycogen metabolism pathways contribute to proinflammatory macrophage activation and suscep...

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Main Authors: Jingwei Ma, Keke Wei, Junwei Liu, Ke Tang, Huafeng Zhang, Liyan Zhu, Jie Chen, Fei Li, Pingwei Xu, Jincheng Liu, Haiqing Fang, Liang Tang, Dianheng Wang, Liping Zeng, Weiwei Sun, Jing Xie, Yuying Liu, Bo Huang
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/5147ac64c2054a77adfffdcb6f32df95
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Summary:Glycogen can be metabolized via glycogenolysis and the pentose phosphate pathway as well as into the production of UDP glucose, which when secreted can bind the P2Y14 receptor. Here the authors show how these glycogen metabolism pathways contribute to proinflammatory macrophage activation and susceptibility to sepsis.

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