Expression and Significance of AQP3 in Cutaneous Lesions

Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis. The aim of this study was to reveal the expression and significance of AQP3 in cutaneous lesions. We analyzed AQP3 mRNA levels using RT-PCR in 311 cutaneous lesions and confirmed AQP3 expression in these lesions b...

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Autores principales:	Dongfeng Niu, Yanhua Bai, Qian Yao, Wei Hou, Lixin Zhou, Xiaozheng Huang, Chen Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/514a5c20d05441e8a963716fa49cc620
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spelling	oai:doaj.org-article:514a5c20d05441e8a963716fa49cc6202021-11-08T02:37:30ZExpression and Significance of AQP3 in Cutaneous Lesions2210-718510.1155/2021/7866471https://doaj.org/article/514a5c20d05441e8a963716fa49cc6202021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7866471https://doaj.org/toc/2210-7185Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis. The aim of this study was to reveal the expression and significance of AQP3 in cutaneous lesions. We analyzed AQP3 mRNA levels using RT-PCR in 311 cutaneous lesions and confirmed AQP3 expression in these lesions by immunohistochemistry. AQP3 mRNA was detected in normal epidermis, seborrheic keratosis, solar keratosis, Bowen’s disease, squamous cell carcinoma, eccrine poroma, apocrine carcinoma, and sebaceoma; however, AQP3 mRNA was absent in basal cell carcinoma, nevocellular nevus, or malignant melanoma. By immunohistochemistry, diffuse AQP3 expression was seen in all keratotic lesions including seborrheic keratosis, verruca vulgaris, molluscum contagiosum, solar keratosis, Bowen’s disease, and squamous cell carcinoma. Diffuse AQP3 expression was also present in all extramammary Paget’s disease. No AQP3 staining was obtained in basal cell carcinoma. Positive AQP3 staining was seen in sweat gland tumors including hidradenoma, eccrine poroma, and apocrine carcinoma. Among sebaceous tumors, AQP3 expressed diffusely in all sebaceous hyperplasia and sebaceous adenoma, but not in sebaceous carcinomas. Only focal AQP3 staining was seen in nevocellular nevus and no AQP3 staining in melanoma. Our findings indicate the function of AQP3 maintained in most skin tumors. AQP3 may be used for differential diagnosis in skin tumors.Dongfeng NiuYanhua BaiQian YaoWei HouLixin ZhouXiaozheng HuangChen ZhaoHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENAnalytical Cellular Pathology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Dongfeng Niu Yanhua Bai Qian Yao Wei Hou Lixin Zhou Xiaozheng Huang Chen Zhao Expression and Significance of AQP3 in Cutaneous Lesions
description	Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis. The aim of this study was to reveal the expression and significance of AQP3 in cutaneous lesions. We analyzed AQP3 mRNA levels using RT-PCR in 311 cutaneous lesions and confirmed AQP3 expression in these lesions by immunohistochemistry. AQP3 mRNA was detected in normal epidermis, seborrheic keratosis, solar keratosis, Bowen’s disease, squamous cell carcinoma, eccrine poroma, apocrine carcinoma, and sebaceoma; however, AQP3 mRNA was absent in basal cell carcinoma, nevocellular nevus, or malignant melanoma. By immunohistochemistry, diffuse AQP3 expression was seen in all keratotic lesions including seborrheic keratosis, verruca vulgaris, molluscum contagiosum, solar keratosis, Bowen’s disease, and squamous cell carcinoma. Diffuse AQP3 expression was also present in all extramammary Paget’s disease. No AQP3 staining was obtained in basal cell carcinoma. Positive AQP3 staining was seen in sweat gland tumors including hidradenoma, eccrine poroma, and apocrine carcinoma. Among sebaceous tumors, AQP3 expressed diffusely in all sebaceous hyperplasia and sebaceous adenoma, but not in sebaceous carcinomas. Only focal AQP3 staining was seen in nevocellular nevus and no AQP3 staining in melanoma. Our findings indicate the function of AQP3 maintained in most skin tumors. AQP3 may be used for differential diagnosis in skin tumors.
format	article
author	Dongfeng Niu Yanhua Bai Qian Yao Wei Hou Lixin Zhou Xiaozheng Huang Chen Zhao
author_facet	Dongfeng Niu Yanhua Bai Qian Yao Wei Hou Lixin Zhou Xiaozheng Huang Chen Zhao
author_sort	Dongfeng Niu
title	Expression and Significance of AQP3 in Cutaneous Lesions
title_short	Expression and Significance of AQP3 in Cutaneous Lesions
title_full	Expression and Significance of AQP3 in Cutaneous Lesions
title_fullStr	Expression and Significance of AQP3 in Cutaneous Lesions
title_full_unstemmed	Expression and Significance of AQP3 in Cutaneous Lesions
title_sort	expression and significance of aqp3 in cutaneous lesions
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/514a5c20d05441e8a963716fa49cc620
work_keys_str_mv	AT dongfengniu expressionandsignificanceofaqp3incutaneouslesions AT yanhuabai expressionandsignificanceofaqp3incutaneouslesions AT qianyao expressionandsignificanceofaqp3incutaneouslesions AT weihou expressionandsignificanceofaqp3incutaneouslesions AT lixinzhou expressionandsignificanceofaqp3incutaneouslesions AT xiaozhenghuang expressionandsignificanceofaqp3incutaneouslesions AT chenzhao expressionandsignificanceofaqp3incutaneouslesions
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Expression and Significance of AQP3 in Cutaneous Lesions

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