Cortical proteins may provide motor resilience in older adults

Abstract Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologies that provide motor resilience. We studied 1226 o...

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Autores principales:	Aron S. Buchman, Lei Yu, Shahram Oveisgharan, Vladislav A. Petyuk, Shinya Tasaki, Chris Gaiteri, Robert S. Wilson, Francine Grodstein, Julie A. Schneider, Hans-Ulrich Klein, Philip L. De Jager, David A. Bennett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/514ab8f92015428598a8892c4c1b5d47
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spelling	oai:doaj.org-article:514ab8f92015428598a8892c4c1b5d472021-12-02T15:49:40ZCortical proteins may provide motor resilience in older adults10.1038/s41598-021-90859-32045-2322https://doaj.org/article/514ab8f92015428598a8892c4c1b5d472021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90859-3https://doaj.org/toc/2045-2322Abstract Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologies that provide motor resilience. We studied 1226 older decedents with annual motor testing, postmortem brain pathologies and quantified 226 proteotypic peptides in prefrontal cortex. Twenty peptides remained associated with motor decline in models controlling for ten brain pathologies (FDR < 0.05). Higher levels of nine peptides and lower levels of eleven peptides were related to slower decline. A higher motor resilience protein score based on averaging the levels of all 20 peptides was related to slower motor decline, less severe parkinsonism and lower odds of mobility disability before death. Cortical proteins may provide motor resilience. Targeting these proteins in further drug discovery may yield novel interventions to maintain motor function in old age.Aron S. BuchmanLei YuShahram OveisgharanVladislav A. PetyukShinya TasakiChris GaiteriRobert S. WilsonFrancine GrodsteinJulie A. SchneiderHans-Ulrich KleinPhilip L. De JagerDavid A. BennettNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aron S. Buchman Lei Yu Shahram Oveisgharan Vladislav A. Petyuk Shinya Tasaki Chris Gaiteri Robert S. Wilson Francine Grodstein Julie A. Schneider Hans-Ulrich Klein Philip L. De Jager David A. Bennett Cortical proteins may provide motor resilience in older adults
description	Abstract Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologies that provide motor resilience. We studied 1226 older decedents with annual motor testing, postmortem brain pathologies and quantified 226 proteotypic peptides in prefrontal cortex. Twenty peptides remained associated with motor decline in models controlling for ten brain pathologies (FDR < 0.05). Higher levels of nine peptides and lower levels of eleven peptides were related to slower decline. A higher motor resilience protein score based on averaging the levels of all 20 peptides was related to slower motor decline, less severe parkinsonism and lower odds of mobility disability before death. Cortical proteins may provide motor resilience. Targeting these proteins in further drug discovery may yield novel interventions to maintain motor function in old age.
format	article
author	Aron S. Buchman Lei Yu Shahram Oveisgharan Vladislav A. Petyuk Shinya Tasaki Chris Gaiteri Robert S. Wilson Francine Grodstein Julie A. Schneider Hans-Ulrich Klein Philip L. De Jager David A. Bennett
author_facet	Aron S. Buchman Lei Yu Shahram Oveisgharan Vladislav A. Petyuk Shinya Tasaki Chris Gaiteri Robert S. Wilson Francine Grodstein Julie A. Schneider Hans-Ulrich Klein Philip L. De Jager David A. Bennett
author_sort	Aron S. Buchman
title	Cortical proteins may provide motor resilience in older adults
title_short	Cortical proteins may provide motor resilience in older adults
title_full	Cortical proteins may provide motor resilience in older adults
title_fullStr	Cortical proteins may provide motor resilience in older adults
title_full_unstemmed	Cortical proteins may provide motor resilience in older adults
title_sort	cortical proteins may provide motor resilience in older adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/514ab8f92015428598a8892c4c1b5d47
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Cortical proteins may provide motor resilience in older adults

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