Cognitive deficits in familial schizophrenia

Background: Cognitive impairment is a core feature of schizophrenia and has been observed in subjects with and without a family history of schizophrenia. Nonetheless, there is a paucity of research directly contrasting cognitive profiles in schizophrenia patients and normal people where family histo...

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Autores principales:	Aneek Saha, Ekram Goel, Madhura Samudra, Suprakash Chaudhury, Daniel Saldanha
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	cognitive deficits familial schizophrenia pgi battery of brain dysfunction positive and negative syndrome scale verbal memory visual memory working memory Psychiatry RC435-571 Industrial psychology HF5548.7-5548.85
Acceso en línea:	https://doaj.org/article/514ae1b621c44080a94126af4728d59a
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spelling	oai:doaj.org-article:514ae1b621c44080a94126af4728d59a2021-11-12T10:11:30ZCognitive deficits in familial schizophrenia0972-67480976-279510.4103/0972-6748.328793https://doaj.org/article/514ae1b621c44080a94126af4728d59a2021-01-01T00:00:00Zhttp://www.industrialpsychiatry.org/article.asp?issn=0972-6748;year=2021;volume=30;issue=3;spage=83;epage=88;aulast=Sahahttps://doaj.org/toc/0972-6748https://doaj.org/toc/0976-2795Background: Cognitive impairment is a core feature of schizophrenia and has been observed in subjects with and without a family history of schizophrenia. Nonetheless, there is a paucity of research directly contrasting cognitive profiles in schizophrenia patients and normal people where family history is present and those where the family history is absent. Aim: This stydy aimed to compare cognitive functions in patients with schizophrenia who had a family history with those that did not and healthy controls. Materials and Methods: Fifty consecutive schizophrenia patients were assessed on admission and follow-up after 6 months of treatment using a specially prepared pro forma, the Positive and Negative Syndrome Scale, and the PGI Battery of brain dysfunction is the name give to the test. An equal number of age- and sex-matched normal control subjects were also assessed. Results: Visual memory scores in this study show improvement between baseline and follow-up in schizophrenia patients with/without a family history. Both verbal learning and memory increase between baseline and follow-up but do not reach control levels. Reasoning and problem-solving deficits follow a similar pattern and are causative in the inability to adapt to a changing world. Speed of processing shows improvement with treatment. Working memory deficits in patients improve with treatment. Conclusions: In this study, all six cognitive domain scores in schizophrenia improved after 6 months of treatment but did not reach the control population level. Individuals with the highest cognitive deficits in the scales were the ones who had a family history of schizophrenia.Aneek SahaEkram GoelMadhura SamudraSuprakash ChaudhuryDaniel SaldanhaWolters Kluwer Medknow Publicationsarticlecognitive deficitsfamilial schizophreniapgi battery of brain dysfunctionpositive and negative syndrome scaleverbal memoryvisual memoryworking memoryPsychiatryRC435-571Industrial psychologyHF5548.7-5548.85ENIndustrial Psychiatry Journal, Vol 30, Iss 3, Pp 83-88 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognitive deficits familial schizophrenia pgi battery of brain dysfunction positive and negative syndrome scale verbal memory visual memory working memory Psychiatry RC435-571 Industrial psychology HF5548.7-5548.85
spellingShingle	cognitive deficits familial schizophrenia pgi battery of brain dysfunction positive and negative syndrome scale verbal memory visual memory working memory Psychiatry RC435-571 Industrial psychology HF5548.7-5548.85 Aneek Saha Ekram Goel Madhura Samudra Suprakash Chaudhury Daniel Saldanha Cognitive deficits in familial schizophrenia
description	Background: Cognitive impairment is a core feature of schizophrenia and has been observed in subjects with and without a family history of schizophrenia. Nonetheless, there is a paucity of research directly contrasting cognitive profiles in schizophrenia patients and normal people where family history is present and those where the family history is absent. Aim: This stydy aimed to compare cognitive functions in patients with schizophrenia who had a family history with those that did not and healthy controls. Materials and Methods: Fifty consecutive schizophrenia patients were assessed on admission and follow-up after 6 months of treatment using a specially prepared pro forma, the Positive and Negative Syndrome Scale, and the PGI Battery of brain dysfunction is the name give to the test. An equal number of age- and sex-matched normal control subjects were also assessed. Results: Visual memory scores in this study show improvement between baseline and follow-up in schizophrenia patients with/without a family history. Both verbal learning and memory increase between baseline and follow-up but do not reach control levels. Reasoning and problem-solving deficits follow a similar pattern and are causative in the inability to adapt to a changing world. Speed of processing shows improvement with treatment. Working memory deficits in patients improve with treatment. Conclusions: In this study, all six cognitive domain scores in schizophrenia improved after 6 months of treatment but did not reach the control population level. Individuals with the highest cognitive deficits in the scales were the ones who had a family history of schizophrenia.
format	article
author	Aneek Saha Ekram Goel Madhura Samudra Suprakash Chaudhury Daniel Saldanha
author_facet	Aneek Saha Ekram Goel Madhura Samudra Suprakash Chaudhury Daniel Saldanha
author_sort	Aneek Saha
title	Cognitive deficits in familial schizophrenia
title_short	Cognitive deficits in familial schizophrenia
title_full	Cognitive deficits in familial schizophrenia
title_fullStr	Cognitive deficits in familial schizophrenia
title_full_unstemmed	Cognitive deficits in familial schizophrenia
title_sort	cognitive deficits in familial schizophrenia
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/514ae1b621c44080a94126af4728d59a
work_keys_str_mv	AT aneeksaha cognitivedeficitsinfamilialschizophrenia AT ekramgoel cognitivedeficitsinfamilialschizophrenia AT madhurasamudra cognitivedeficitsinfamilialschizophrenia AT suprakashchaudhury cognitivedeficitsinfamilialschizophrenia AT danielsaldanha cognitivedeficitsinfamilialschizophrenia
_version_	1718430987910643712

Cognitive deficits in familial schizophrenia

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