Cancer associated fibroblast FAK regulates malignant cell metabolism

Cancer associated fibroblasts (CAFs) have been suggested to regulate cancer cell metabolism, but the mechanisms are not completely elucidated. Here, the authors show that low FAK expression in stromal cells correlates with poor prognosis in breast and pancreatic cancer patients and that FAK-silencin...

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Autores principales:	Fevzi Demircioglu, Jun Wang, Juliana Candido, Ana S. H. Costa, Pedro Casado, Beatriz de Luxan Delgado, Louise E. Reynolds, Jesus Gomez-Escudero, Emma Newport, Vinothini Rajeeve, Ann-Marie Baker, Marina Roy-Luzarraga, Trevor A. Graham, Julie Foster, Yu Wang, James J. Campbell, Rajinder Singh, Penglie Zhang, Thomas J. Schall, Frances R. Balkwill, Jane Sosabowski, Pedro R. Cutillas, Christian Frezza, Patricia Sancho, Kairbaan Hodivala-Dilke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/514da35f7c834a7f879f285d226a9e53
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:514da35f7c834a7f879f285d226a9e532021-12-02T17:32:42ZCancer associated fibroblast FAK regulates malignant cell metabolism10.1038/s41467-020-15104-32041-1723https://doaj.org/article/514da35f7c834a7f879f285d226a9e532020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15104-3https://doaj.org/toc/2041-1723Cancer associated fibroblasts (CAFs) have been suggested to regulate cancer cell metabolism, but the mechanisms are not completely elucidated. Here, the authors show that low FAK expression in stromal cells correlates with poor prognosis in breast and pancreatic cancer patients and that FAK-silencing in CAFs promotes tumourigenesis by the paracrine regulation of cancer cell metabolism.Fevzi DemirciogluJun WangJuliana CandidoAna S. H. CostaPedro CasadoBeatriz de Luxan DelgadoLouise E. ReynoldsJesus Gomez-EscuderoEmma NewportVinothini RajeeveAnn-Marie BakerMarina Roy-LuzarragaTrevor A. GrahamJulie FosterYu WangJames J. CampbellRajinder SinghPenglie ZhangThomas J. SchallFrances R. BalkwillJane SosabowskiPedro R. CutillasChristian FrezzaPatricia SanchoKairbaan Hodivala-DilkeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fevzi Demircioglu Jun Wang Juliana Candido Ana S. H. Costa Pedro Casado Beatriz de Luxan Delgado Louise E. Reynolds Jesus Gomez-Escudero Emma Newport Vinothini Rajeeve Ann-Marie Baker Marina Roy-Luzarraga Trevor A. Graham Julie Foster Yu Wang James J. Campbell Rajinder Singh Penglie Zhang Thomas J. Schall Frances R. Balkwill Jane Sosabowski Pedro R. Cutillas Christian Frezza Patricia Sancho Kairbaan Hodivala-Dilke Cancer associated fibroblast FAK regulates malignant cell metabolism
description	Cancer associated fibroblasts (CAFs) have been suggested to regulate cancer cell metabolism, but the mechanisms are not completely elucidated. Here, the authors show that low FAK expression in stromal cells correlates with poor prognosis in breast and pancreatic cancer patients and that FAK-silencing in CAFs promotes tumourigenesis by the paracrine regulation of cancer cell metabolism.
format	article
author	Fevzi Demircioglu Jun Wang Juliana Candido Ana S. H. Costa Pedro Casado Beatriz de Luxan Delgado Louise E. Reynolds Jesus Gomez-Escudero Emma Newport Vinothini Rajeeve Ann-Marie Baker Marina Roy-Luzarraga Trevor A. Graham Julie Foster Yu Wang James J. Campbell Rajinder Singh Penglie Zhang Thomas J. Schall Frances R. Balkwill Jane Sosabowski Pedro R. Cutillas Christian Frezza Patricia Sancho Kairbaan Hodivala-Dilke
author_facet	Fevzi Demircioglu Jun Wang Juliana Candido Ana S. H. Costa Pedro Casado Beatriz de Luxan Delgado Louise E. Reynolds Jesus Gomez-Escudero Emma Newport Vinothini Rajeeve Ann-Marie Baker Marina Roy-Luzarraga Trevor A. Graham Julie Foster Yu Wang James J. Campbell Rajinder Singh Penglie Zhang Thomas J. Schall Frances R. Balkwill Jane Sosabowski Pedro R. Cutillas Christian Frezza Patricia Sancho Kairbaan Hodivala-Dilke
author_sort	Fevzi Demircioglu
title	Cancer associated fibroblast FAK regulates malignant cell metabolism
title_short	Cancer associated fibroblast FAK regulates malignant cell metabolism
title_full	Cancer associated fibroblast FAK regulates malignant cell metabolism
title_fullStr	Cancer associated fibroblast FAK regulates malignant cell metabolism
title_full_unstemmed	Cancer associated fibroblast FAK regulates malignant cell metabolism
title_sort	cancer associated fibroblast fak regulates malignant cell metabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/514da35f7c834a7f879f285d226a9e53
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Cancer associated fibroblast FAK regulates malignant cell metabolism

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