A Novel Strategy for the Diagnosis of Pulmonary High-Grade Neuroendocrine Tumor

Correctly diagnosing a histologic type of lung cancer is important for selecting the appropriate treatment because the aggressiveness, chemotherapy regimen, surgical approach, and prognosis vary significantly among histologic types. Pulmonary NETs, which are characterized by neuroendocrine morpholog...

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Autores principales:	Kentaro Miura, Kimihiro Shimizu, Shogo Ide, Shuji Mishima, Shunichiro Matsuoka, Tetsu Takeda, Takashi Eguchi, Kazutoshi Hamanaka, Takeshi Uehara
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	high-grade neuroendocrine tumor small cell lung cancer large cell neuroendocrine tumor immunostaining stathmin-1 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/515011ba71ab49848fab7a364e63932e
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spelling	oai:doaj.org-article:515011ba71ab49848fab7a364e63932e2021-11-25T17:20:07ZA Novel Strategy for the Diagnosis of Pulmonary High-Grade Neuroendocrine Tumor10.3390/diagnostics111119452075-4418https://doaj.org/article/515011ba71ab49848fab7a364e63932e2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1945https://doaj.org/toc/2075-4418Correctly diagnosing a histologic type of lung cancer is important for selecting the appropriate treatment because the aggressiveness, chemotherapy regimen, surgical approach, and prognosis vary significantly among histologic types. Pulmonary NETs, which are characterized by neuroendocrine morphologies, represent approximately 20% of all lung cancers. In particular, high-grade neuroendocrine tumors (small cell lung cancer and large cell neuroendocrine tumor) are highly proliferative cancers that have a poorer prognosis than other non-small cell lung cancers. The combination of hematoxylin and eosin staining, Ki-67, and immunostaining of classic neuroendocrine markers, such as chromogranin A, CD56, and synaptophysin, are normally used to diagnose high-grade neuroendocrine tumors; however, they are frequently heterogeneous. This article reviews the diagnostic methods of lung cancer diagnosis focused on immunostaining. In particular, we describe the usefulness of immunostaining by Stathmin-1, which is a cytosolic phosphoprotein and a key regulator of cell division due to its microtubule depolymerization in a phosphorylation-dependent manner, for the diagnosis of high-grade neuroendocrine tumors.Kentaro MiuraKimihiro ShimizuShogo IdeShuji MishimaShunichiro MatsuokaTetsu TakedaTakashi EguchiKazutoshi HamanakaTakeshi UeharaMDPI AGarticlehigh-grade neuroendocrine tumorsmall cell lung cancerlarge cell neuroendocrine tumorimmunostainingstathmin-1Medicine (General)R5-920ENDiagnostics, Vol 11, Iss 1945, p 1945 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	high-grade neuroendocrine tumor small cell lung cancer large cell neuroendocrine tumor immunostaining stathmin-1 Medicine (General) R5-920
spellingShingle	high-grade neuroendocrine tumor small cell lung cancer large cell neuroendocrine tumor immunostaining stathmin-1 Medicine (General) R5-920 Kentaro Miura Kimihiro Shimizu Shogo Ide Shuji Mishima Shunichiro Matsuoka Tetsu Takeda Takashi Eguchi Kazutoshi Hamanaka Takeshi Uehara A Novel Strategy for the Diagnosis of Pulmonary High-Grade Neuroendocrine Tumor
description	Correctly diagnosing a histologic type of lung cancer is important for selecting the appropriate treatment because the aggressiveness, chemotherapy regimen, surgical approach, and prognosis vary significantly among histologic types. Pulmonary NETs, which are characterized by neuroendocrine morphologies, represent approximately 20% of all lung cancers. In particular, high-grade neuroendocrine tumors (small cell lung cancer and large cell neuroendocrine tumor) are highly proliferative cancers that have a poorer prognosis than other non-small cell lung cancers. The combination of hematoxylin and eosin staining, Ki-67, and immunostaining of classic neuroendocrine markers, such as chromogranin A, CD56, and synaptophysin, are normally used to diagnose high-grade neuroendocrine tumors; however, they are frequently heterogeneous. This article reviews the diagnostic methods of lung cancer diagnosis focused on immunostaining. In particular, we describe the usefulness of immunostaining by Stathmin-1, which is a cytosolic phosphoprotein and a key regulator of cell division due to its microtubule depolymerization in a phosphorylation-dependent manner, for the diagnosis of high-grade neuroendocrine tumors.
format	article
author	Kentaro Miura Kimihiro Shimizu Shogo Ide Shuji Mishima Shunichiro Matsuoka Tetsu Takeda Takashi Eguchi Kazutoshi Hamanaka Takeshi Uehara
author_facet	Kentaro Miura Kimihiro Shimizu Shogo Ide Shuji Mishima Shunichiro Matsuoka Tetsu Takeda Takashi Eguchi Kazutoshi Hamanaka Takeshi Uehara
author_sort	Kentaro Miura
title	A Novel Strategy for the Diagnosis of Pulmonary High-Grade Neuroendocrine Tumor
title_short	A Novel Strategy for the Diagnosis of Pulmonary High-Grade Neuroendocrine Tumor
title_full	A Novel Strategy for the Diagnosis of Pulmonary High-Grade Neuroendocrine Tumor
title_fullStr	A Novel Strategy for the Diagnosis of Pulmonary High-Grade Neuroendocrine Tumor
title_full_unstemmed	A Novel Strategy for the Diagnosis of Pulmonary High-Grade Neuroendocrine Tumor
title_sort	novel strategy for the diagnosis of pulmonary high-grade neuroendocrine tumor
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/515011ba71ab49848fab7a364e63932e
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A Novel Strategy for the Diagnosis of Pulmonary High-Grade Neuroendocrine Tumor

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