Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence

Abstract Early childhood caries (ECC) recurrence occurs in approximately 40% of treated cases within one year. The association of Streptococcus mutans and Candida albicans with the onset of ECC is well known. Also, S. mutans strains harboring collagen-binding proteins (Cbps) avidly bind to collagen-...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	B. A. Garcia, N. C. Acosta, S. L. Tomar, L. F. W. Roesch, J. A. Lemos, L. R. F. Mugayar, J. Abranches
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5153742987a949b496c6bfd769d0bde4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5153742987a949b496c6bfd769d0bde4
record_format	dspace
spelling	oai:doaj.org-article:5153742987a949b496c6bfd769d0bde42021-12-02T15:49:28ZAssociation of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence10.1038/s41598-021-90198-32045-2322https://doaj.org/article/5153742987a949b496c6bfd769d0bde42021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90198-3https://doaj.org/toc/2045-2322Abstract Early childhood caries (ECC) recurrence occurs in approximately 40% of treated cases within one year. The association of Streptococcus mutans and Candida albicans with the onset of ECC is well known. Also, S. mutans strains harboring collagen-binding proteins (Cbps) avidly bind to collagen-rich dentin and are linked to increased caries risk. Here, we investigated the presence of Cbp+ S. mutans and C. albicans in saliva and dental plaque of children with varying caries statuses, and their salivary microbiome. In this cross-sectional study, 143 children who were caries-free (n = 73), treated for ECC with no signs of recurrence after 6 months (n = 45), or treated for ECC and experiencing recurrence within 6 months following treatment (n = 25) were enrolled. Co-infection with C. albicans and S. mutans, especially Cbp+ S. mutans, was strongly associated with caries recurrence. Subjects of the recurrence group infected with Cbp+ S. mutans showed a greater burden of Candida spp. and of Mutans streptococci in dentin than those infected with Cbp- strains. Salivary microbiome analysis revealed that Streptococcus parasanguinis was overrepresented in the caries recurrence group. Our findings indicate that Cbp+ S. mutans and C. albicans are intimately associated with caries recurrence, contributing to the establishment of recalcitrant biofilms.B. A. GarciaN. C. AcostaS. L. TomarL. F. W. RoeschJ. A. LemosL. R. F. MugayarJ. AbranchesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q B. A. Garcia N. C. Acosta S. L. Tomar L. F. W. Roesch J. A. Lemos L. R. F. Mugayar J. Abranches Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence
description	Abstract Early childhood caries (ECC) recurrence occurs in approximately 40% of treated cases within one year. The association of Streptococcus mutans and Candida albicans with the onset of ECC is well known. Also, S. mutans strains harboring collagen-binding proteins (Cbps) avidly bind to collagen-rich dentin and are linked to increased caries risk. Here, we investigated the presence of Cbp+ S. mutans and C. albicans in saliva and dental plaque of children with varying caries statuses, and their salivary microbiome. In this cross-sectional study, 143 children who were caries-free (n = 73), treated for ECC with no signs of recurrence after 6 months (n = 45), or treated for ECC and experiencing recurrence within 6 months following treatment (n = 25) were enrolled. Co-infection with C. albicans and S. mutans, especially Cbp+ S. mutans, was strongly associated with caries recurrence. Subjects of the recurrence group infected with Cbp+ S. mutans showed a greater burden of Candida spp. and of Mutans streptococci in dentin than those infected with Cbp- strains. Salivary microbiome analysis revealed that Streptococcus parasanguinis was overrepresented in the caries recurrence group. Our findings indicate that Cbp+ S. mutans and C. albicans are intimately associated with caries recurrence, contributing to the establishment of recalcitrant biofilms.
format	article
author	B. A. Garcia N. C. Acosta S. L. Tomar L. F. W. Roesch J. A. Lemos L. R. F. Mugayar J. Abranches
author_facet	B. A. Garcia N. C. Acosta S. L. Tomar L. F. W. Roesch J. A. Lemos L. R. F. Mugayar J. Abranches
author_sort	B. A. Garcia
title	Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence
title_short	Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence
title_full	Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence
title_fullStr	Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence
title_full_unstemmed	Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence
title_sort	association of candida albicans and cbp+ streptococcus mutans with early childhood caries recurrence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5153742987a949b496c6bfd769d0bde4
work_keys_str_mv	AT bagarcia associationofcandidaalbicansandcbpstreptococcusmutanswithearlychildhoodcariesrecurrence AT ncacosta associationofcandidaalbicansandcbpstreptococcusmutanswithearlychildhoodcariesrecurrence AT sltomar associationofcandidaalbicansandcbpstreptococcusmutanswithearlychildhoodcariesrecurrence AT lfwroesch associationofcandidaalbicansandcbpstreptococcusmutanswithearlychildhoodcariesrecurrence AT jalemos associationofcandidaalbicansandcbpstreptococcusmutanswithearlychildhoodcariesrecurrence AT lrfmugayar associationofcandidaalbicansandcbpstreptococcusmutanswithearlychildhoodcariesrecurrence AT jabranches associationofcandidaalbicansandcbpstreptococcusmutanswithearlychildhoodcariesrecurrence
_version_	1718385688781520896

Association of Candida albicans and Cbp+ Streptococcus mutans with early childhood caries recurrence

Ejemplares similares