Hollow CeO2 with ROS-Scavenging Activity to Alleviate Colitis in Mice
Jing Yang,1,* Jinzhe Zhou,2,* Yingying Zhao,1 Liangchen Zhu,2 Guanghong Luo,3 BuJun Ge2 1Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, People’s Republic of China; 2Department of...
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Dove Medical Press
2021
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oai:doaj.org-article:5154cff250344f3cb8e647bc4b4a05f72021-12-02T18:01:51ZHollow CeO2 with ROS-Scavenging Activity to Alleviate Colitis in Mice1178-2013https://doaj.org/article/5154cff250344f3cb8e647bc4b4a05f72021-10-01T00:00:00Zhttps://www.dovepress.com/hollow-ceo2-with-ros-scavenging-activity-to-alleviate-colitis-in-mice-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Jing Yang,1,* Jinzhe Zhou,2,* Yingying Zhao,1 Liangchen Zhu,2 Guanghong Luo,3 BuJun Ge2 1Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, People’s Republic of China; 2Department of General Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 3Department of Radiation Oncology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanghong Luo; Bujun Ge Email luo.guanghong@szhospital.com; gbj109@126.comIntroduction: Excessive production of reactive oxygen species (ROS) to induce high oxidative stress is one of the main causes of colitis; thus, it has been regarded as a therapeutic target for colitis treatment. And the nanomaterial-based therapeutic strategies are effective against colitis. However, the previous elaborately designed materials exhibit limited application due to the uncertain biocompatibility and complicated manufacturing processes.Methods: In this study, the highly monodisperse hollow CeO2 nanoparticles (H-CeO2) with uniform morphology were obtained by in situ growing CeO2 on solid silica nanoparticles and subsequently removing the silica core. The H-CeO2 was further modified with PEG, which owned excellent biological stability and biocompatibility. The experimental model of colitis induced by dextran sulfate sodium (DSS) was used to investigate the anti-inflammatory effect of H-CeO2-PEG.Results: The H-CeO2-PEG showed good ROS scavenging efficacy and decreased the levels of proinflammatory cytokines (IL-6, IL-1β, IL-18, and TNF-α) in DSS-induced colitis mice. Furthermore, H-CeO2-PEG inhibited the activation of the MAPK signalling pathway to alleviate colitis.Conclusion: This study reveals the therapeutic effects of CeO2-based nanomedicine toward colitis and elucidates the specific signalling pathway involved, which provides potential alternative therapeutic options for patients with inflammation tissue.Keywords: hollow CeO2, ROS, inflammation, colitis, MAPK signalling pathwayYang JZhou JZhao YZhu LLuo GGe BDove Medical Pressarticlehollow ceo2rosinflammationcolitismapk signalling pathwayMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 6889-6904 (2021) |
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hollow ceo2 ros inflammation colitis mapk signalling pathway Medicine (General) R5-920 |
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hollow ceo2 ros inflammation colitis mapk signalling pathway Medicine (General) R5-920 Yang J Zhou J Zhao Y Zhu L Luo G Ge B Hollow CeO2 with ROS-Scavenging Activity to Alleviate Colitis in Mice |
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Jing Yang,1,* Jinzhe Zhou,2,* Yingying Zhao,1 Liangchen Zhu,2 Guanghong Luo,3 BuJun Ge2 1Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, People’s Republic of China; 2Department of General Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 3Department of Radiation Oncology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanghong Luo; Bujun Ge Email luo.guanghong@szhospital.com; gbj109@126.comIntroduction: Excessive production of reactive oxygen species (ROS) to induce high oxidative stress is one of the main causes of colitis; thus, it has been regarded as a therapeutic target for colitis treatment. And the nanomaterial-based therapeutic strategies are effective against colitis. However, the previous elaborately designed materials exhibit limited application due to the uncertain biocompatibility and complicated manufacturing processes.Methods: In this study, the highly monodisperse hollow CeO2 nanoparticles (H-CeO2) with uniform morphology were obtained by in situ growing CeO2 on solid silica nanoparticles and subsequently removing the silica core. The H-CeO2 was further modified with PEG, which owned excellent biological stability and biocompatibility. The experimental model of colitis induced by dextran sulfate sodium (DSS) was used to investigate the anti-inflammatory effect of H-CeO2-PEG.Results: The H-CeO2-PEG showed good ROS scavenging efficacy and decreased the levels of proinflammatory cytokines (IL-6, IL-1β, IL-18, and TNF-α) in DSS-induced colitis mice. Furthermore, H-CeO2-PEG inhibited the activation of the MAPK signalling pathway to alleviate colitis.Conclusion: This study reveals the therapeutic effects of CeO2-based nanomedicine toward colitis and elucidates the specific signalling pathway involved, which provides potential alternative therapeutic options for patients with inflammation tissue.Keywords: hollow CeO2, ROS, inflammation, colitis, MAPK signalling pathway |
| format |
article |
| author |
Yang J Zhou J Zhao Y Zhu L Luo G Ge B |
| author_facet |
Yang J Zhou J Zhao Y Zhu L Luo G Ge B |
| author_sort |
Yang J |
| title |
Hollow CeO2 with ROS-Scavenging Activity to Alleviate Colitis in Mice |
| title_short |
Hollow CeO2 with ROS-Scavenging Activity to Alleviate Colitis in Mice |
| title_full |
Hollow CeO2 with ROS-Scavenging Activity to Alleviate Colitis in Mice |
| title_fullStr |
Hollow CeO2 with ROS-Scavenging Activity to Alleviate Colitis in Mice |
| title_full_unstemmed |
Hollow CeO2 with ROS-Scavenging Activity to Alleviate Colitis in Mice |
| title_sort |
hollow ceo2 with ros-scavenging activity to alleviate colitis in mice |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/5154cff250344f3cb8e647bc4b4a05f7 |
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