Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

Dopamine agonists increase brain glutathione levels. Here the authors identify noncanonical signalling by Nrf2 as a potential mechanism for the neuroprotective effects of dopamine D2 receptor activation.

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Autores principales: Yao Wei, Ming Lu, Meng Mei, Haoran Wang, Zhitao Han, Miaomiao Chen, Hang Yao, Nanshan Song, Xiao Ding, Jianhua Ding, Ming Xiao, Gang Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/5156e6f9d55642859a89acad2f5bd747
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spelling oai:doaj.org-article:5156e6f9d55642859a89acad2f5bd7472021-12-02T16:49:45ZPyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection10.1038/s41467-020-14788-x2041-1723https://doaj.org/article/5156e6f9d55642859a89acad2f5bd7472020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14788-xhttps://doaj.org/toc/2041-1723Dopamine agonists increase brain glutathione levels. Here the authors identify noncanonical signalling by Nrf2 as a potential mechanism for the neuroprotective effects of dopamine D2 receptor activation.Yao WeiMing LuMeng MeiHaoran WangZhitao HanMiaomiao ChenHang YaoNanshan SongXiao DingJianhua DingMing XiaoGang HuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yao Wei
Ming Lu
Meng Mei
Haoran Wang
Zhitao Han
Miaomiao Chen
Hang Yao
Nanshan Song
Xiao Ding
Jianhua Ding
Ming Xiao
Gang Hu
Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
description Dopamine agonists increase brain glutathione levels. Here the authors identify noncanonical signalling by Nrf2 as a potential mechanism for the neuroprotective effects of dopamine D2 receptor activation.
format article
author Yao Wei
Ming Lu
Meng Mei
Haoran Wang
Zhitao Han
Miaomiao Chen
Hang Yao
Nanshan Song
Xiao Ding
Jianhua Ding
Ming Xiao
Gang Hu
author_facet Yao Wei
Ming Lu
Meng Mei
Haoran Wang
Zhitao Han
Miaomiao Chen
Hang Yao
Nanshan Song
Xiao Ding
Jianhua Ding
Ming Xiao
Gang Hu
author_sort Yao Wei
title Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
title_short Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
title_full Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
title_fullStr Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
title_full_unstemmed Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection
title_sort pyridoxine induces glutathione synthesis via pkm2-mediated nrf2 transactivation and confers neuroprotection
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/5156e6f9d55642859a89acad2f5bd747
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