FEATURES OF IMMUNE CELLS IN ACUTE LYMPHOBLASTIC LEUKEMIA

Abstract. In this study, we have identified functional features of immune system cells in patients with acute lymphoblastic leukemia (ALL), depending on clinical stage of the disease. At all stages of the disease, the patients developed T-cell immunodeficiency. A decrease in T lymphocyte scores and...

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Autores principales:	O. V. Smirnova, V. T. Manchuk
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immunity acute lymphoblastic leukemia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/515be66caee043b68e7517a18b52e79c
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spelling	oai:doaj.org-article:515be66caee043b68e7517a18b52e79c2021-11-18T08:03:43ZFEATURES OF IMMUNE CELLS IN ACUTE LYMPHOBLASTIC LEUKEMIA1563-06252313-741X10.15789/1563-0625-2013-6-577-584https://doaj.org/article/515be66caee043b68e7517a18b52e79c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/668https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. In this study, we have identified functional features of immune system cells in patients with acute lymphoblastic leukemia (ALL), depending on clinical stage of the disease. At all stages of the disease, the patients developed T-cell immunodeficiency. A decrease in T lymphocyte scores and diminished CD4/CD8 ratio was associated with development of primary ALL attack. An increase in NK-cells was typical to ALL relapse. In general, ALL cell populations were characterized by a significant reduction of intracellular metabolic processes in lymphocytes. Chemiluminescent activity of neutrophil granulocytes changed in ALL patients with disease progression, being intensified at the stage of primary attack, followed be decreased activity during complete clinical remission and relapse, probably, due to depletion of internal reserves. The study confirmed that significant changes in ALL are associated with functional and metabolic state of lymphocytes and neutrophils upon progression of the disease, which is probably responsible both for development of complications, but it also may influence relapse risks and determine worse prognosis in general.O. V. SmirnovaV. T. ManchukSPb RAACIarticleimmunityacute lymphoblastic leukemiaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 6, Pp 577-584 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immunity acute lymphoblastic leukemia Immunologic diseases. Allergy RC581-607
spellingShingle	immunity acute lymphoblastic leukemia Immunologic diseases. Allergy RC581-607 O. V. Smirnova V. T. Manchuk FEATURES OF IMMUNE CELLS IN ACUTE LYMPHOBLASTIC LEUKEMIA
description	Abstract. In this study, we have identified functional features of immune system cells in patients with acute lymphoblastic leukemia (ALL), depending on clinical stage of the disease. At all stages of the disease, the patients developed T-cell immunodeficiency. A decrease in T lymphocyte scores and diminished CD4/CD8 ratio was associated with development of primary ALL attack. An increase in NK-cells was typical to ALL relapse. In general, ALL cell populations were characterized by a significant reduction of intracellular metabolic processes in lymphocytes. Chemiluminescent activity of neutrophil granulocytes changed in ALL patients with disease progression, being intensified at the stage of primary attack, followed be decreased activity during complete clinical remission and relapse, probably, due to depletion of internal reserves. The study confirmed that significant changes in ALL are associated with functional and metabolic state of lymphocytes and neutrophils upon progression of the disease, which is probably responsible both for development of complications, but it also may influence relapse risks and determine worse prognosis in general.
format	article
author	O. V. Smirnova V. T. Manchuk
author_facet	O. V. Smirnova V. T. Manchuk
author_sort	O. V. Smirnova
title	FEATURES OF IMMUNE CELLS IN ACUTE LYMPHOBLASTIC LEUKEMIA
title_short	FEATURES OF IMMUNE CELLS IN ACUTE LYMPHOBLASTIC LEUKEMIA
title_full	FEATURES OF IMMUNE CELLS IN ACUTE LYMPHOBLASTIC LEUKEMIA
title_fullStr	FEATURES OF IMMUNE CELLS IN ACUTE LYMPHOBLASTIC LEUKEMIA
title_full_unstemmed	FEATURES OF IMMUNE CELLS IN ACUTE LYMPHOBLASTIC LEUKEMIA
title_sort	features of immune cells in acute lymphoblastic leukemia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/515be66caee043b68e7517a18b52e79c
work_keys_str_mv	AT ovsmirnova featuresofimmunecellsinacutelymphoblasticleukemia AT vtmanchuk featuresofimmunecellsinacutelymphoblasticleukemia
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FEATURES OF IMMUNE CELLS IN ACUTE LYMPHOBLASTIC LEUKEMIA

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