Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever

There is currently no approved vaccine for Lassa fever virus (LASV). Here, Abreu-Mota et al. develop an inactivated, adjuvanted vaccine candidate expressing LASV glycoprotein (GPC) in a rabies virus vector, and show that non-neutralizing LASV GPC-specific antibodies are a major mechanism of protecti...

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Autores principales:	Tiago Abreu-Mota, Katie R. Hagen, Kurt Cooper, Peter B. Jahrling, Gene Tan, Christoph Wirblich, Reed F. Johnson, Matthias J. Schnell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/515d6b50b90b48d2976fee557e117292
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spelling	oai:doaj.org-article:515d6b50b90b48d2976fee557e1172922021-12-02T14:41:17ZNon-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever10.1038/s41467-018-06741-w2041-1723https://doaj.org/article/515d6b50b90b48d2976fee557e1172922018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06741-whttps://doaj.org/toc/2041-1723There is currently no approved vaccine for Lassa fever virus (LASV). Here, Abreu-Mota et al. develop an inactivated, adjuvanted vaccine candidate expressing LASV glycoprotein (GPC) in a rabies virus vector, and show that non-neutralizing LASV GPC-specific antibodies are a major mechanism of protection.Tiago Abreu-MotaKatie R. HagenKurt CooperPeter B. JahrlingGene TanChristoph WirblichReed F. JohnsonMatthias J. SchnellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tiago Abreu-Mota Katie R. Hagen Kurt Cooper Peter B. Jahrling Gene Tan Christoph Wirblich Reed F. Johnson Matthias J. Schnell Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever
description	There is currently no approved vaccine for Lassa fever virus (LASV). Here, Abreu-Mota et al. develop an inactivated, adjuvanted vaccine candidate expressing LASV glycoprotein (GPC) in a rabies virus vector, and show that non-neutralizing LASV GPC-specific antibodies are a major mechanism of protection.
format	article
author	Tiago Abreu-Mota Katie R. Hagen Kurt Cooper Peter B. Jahrling Gene Tan Christoph Wirblich Reed F. Johnson Matthias J. Schnell
author_facet	Tiago Abreu-Mota Katie R. Hagen Kurt Cooper Peter B. Jahrling Gene Tan Christoph Wirblich Reed F. Johnson Matthias J. Schnell
author_sort	Tiago Abreu-Mota
title	Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever
title_short	Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever
title_full	Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever
title_fullStr	Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever
title_full_unstemmed	Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever
title_sort	non-neutralizing antibodies elicited by recombinant lassa–rabies vaccine are critical for protection against lassa fever
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/515d6b50b90b48d2976fee557e117292
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Non-neutralizing antibodies elicited by recombinant Lassa–Rabies vaccine are critical for protection against Lassa fever

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