PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue

Abstract This study evaluated the MRI-derived fat fraction (FF), from a Cooling-reheating protocol, for estimating the cold-induced brown adipose tissue (BAT) metabolic rate of glucose (MRglu) and changes in lipid content, perfusion and arterial blood volume (VA) within cervical-supraclavicular fat...

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Autores principales:	Elin Lundström, Jonathan Andersson, Mathias Engström, Mark Lubberink, Robin Strand, Håkan Ahlström, Joel Kullberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/515dee6025e04e739b1252257d646efc
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spelling	oai:doaj.org-article:515dee6025e04e739b1252257d646efc2021-12-02T16:26:29ZPET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue10.1038/s41598-021-87768-w2045-2322https://doaj.org/article/515dee6025e04e739b1252257d646efc2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87768-whttps://doaj.org/toc/2045-2322Abstract This study evaluated the MRI-derived fat fraction (FF), from a Cooling-reheating protocol, for estimating the cold-induced brown adipose tissue (BAT) metabolic rate of glucose (MRglu) and changes in lipid content, perfusion and arterial blood volume (VA) within cervical-supraclavicular fat (sBAT). Twelve volunteers underwent PET/MRI at baseline, during cold exposure and reheating. For each temperature condition, perfusion and VA were quantified with dynamic [15O]water-PET, and FF, with water-fat MRI. MRglu was assessed with dynamic [18F]fluorodeoxyglucose-PET during cold exposure. sBAT was defined using anatomical criteria, and its subregion sBATHI, by MRglu > 11 μmol/100 cm3/min. For all temperature conditions, sBAT-FF correlated negatively with sBAT-MRglu (ρ ≤ − 0.87). After 3 h of cold, sBAT-FF decreased (− 2.13 percentage points) but tended to normalize during reheating although sBATHI-FF remained low. sBAT-perfusion and sBAT-VA increased during cold exposure (perfusion: + 5.2 ml/100 cm3/min, VA: + 4.0 ml/100 cm3). sBAT-perfusion remained elevated and sBAT-VA normalized during reheating. Regardless of temperature condition during the Cooling-reheating protocol, sBAT-FF could predict the cold-induced sBAT-MRglu. The FF decreases observed after reheating were mainly due to lipid consumption, but could potentially be underestimated due to intracellular lipid replenishment. The influence of perfusion and VA, on the changes in FF observed during cold exposure, could not be ruled out.Elin LundströmJonathan AnderssonMathias EngströmMark LubberinkRobin StrandHåkan AhlströmJoel KullbergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elin Lundström Jonathan Andersson Mathias Engström Mark Lubberink Robin Strand Håkan Ahlström Joel Kullberg PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
description	Abstract This study evaluated the MRI-derived fat fraction (FF), from a Cooling-reheating protocol, for estimating the cold-induced brown adipose tissue (BAT) metabolic rate of glucose (MRglu) and changes in lipid content, perfusion and arterial blood volume (VA) within cervical-supraclavicular fat (sBAT). Twelve volunteers underwent PET/MRI at baseline, during cold exposure and reheating. For each temperature condition, perfusion and VA were quantified with dynamic [15O]water-PET, and FF, with water-fat MRI. MRglu was assessed with dynamic [18F]fluorodeoxyglucose-PET during cold exposure. sBAT was defined using anatomical criteria, and its subregion sBATHI, by MRglu > 11 μmol/100 cm3/min. For all temperature conditions, sBAT-FF correlated negatively with sBAT-MRglu (ρ ≤ − 0.87). After 3 h of cold, sBAT-FF decreased (− 2.13 percentage points) but tended to normalize during reheating although sBATHI-FF remained low. sBAT-perfusion and sBAT-VA increased during cold exposure (perfusion: + 5.2 ml/100 cm3/min, VA: + 4.0 ml/100 cm3). sBAT-perfusion remained elevated and sBAT-VA normalized during reheating. Regardless of temperature condition during the Cooling-reheating protocol, sBAT-FF could predict the cold-induced sBAT-MRglu. The FF decreases observed after reheating were mainly due to lipid consumption, but could potentially be underestimated due to intracellular lipid replenishment. The influence of perfusion and VA, on the changes in FF observed during cold exposure, could not be ruled out.
format	article
author	Elin Lundström Jonathan Andersson Mathias Engström Mark Lubberink Robin Strand Håkan Ahlström Joel Kullberg
author_facet	Elin Lundström Jonathan Andersson Mathias Engström Mark Lubberink Robin Strand Håkan Ahlström Joel Kullberg
author_sort	Elin Lundström
title	PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
title_short	PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
title_full	PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
title_fullStr	PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
title_full_unstemmed	PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
title_sort	pet/mri of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/515dee6025e04e739b1252257d646efc
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PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue

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