Higher VO2max is associated with thicker cortex and lower grey matter blood flow in older adults

Abstract VO2max (maximal oxygen consumption), a validated measure of aerobic fitness, has been associated with better cerebral artery compliance and measures of brain morphology, such as higher cortical thickness (CT) in frontal, temporal and cingular cortices, and larger grey matter volume (GMV) of...

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Autores principales:	Gaia Olivo, Jonna Nilsson, Benjamín Garzón, Alexander Lebedev, Anders Wåhlin, Olga Tarassova, Maria M. Ekblom, Martin Lövdén
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/515f4d44d7154ee6ac48405a623f0f7f
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spelling	oai:doaj.org-article:515f4d44d7154ee6ac48405a623f0f7f2021-12-02T17:08:36ZHigher VO2max is associated with thicker cortex and lower grey matter blood flow in older adults10.1038/s41598-021-96138-52045-2322https://doaj.org/article/515f4d44d7154ee6ac48405a623f0f7f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96138-5https://doaj.org/toc/2045-2322Abstract VO2max (maximal oxygen consumption), a validated measure of aerobic fitness, has been associated with better cerebral artery compliance and measures of brain morphology, such as higher cortical thickness (CT) in frontal, temporal and cingular cortices, and larger grey matter volume (GMV) of the middle temporal gyrus, hippocampus, orbitofrontal cortex and cingulate cortex. Single sessions of physical exercise can promptly enhance cognitive performance and brain activity during executive tasks. However, the immediate effects of exercise on macro-scale properties of the brain’s grey matter remain unclear. We investigated the impact of one session of moderate-intensity physical exercise, compared with rest, on grey matter volume, cortical thickness, working memory performance, and task-related brain activity in older adults. Cross-sectional associations between brain measures and VO2max were also tested. Exercise did not induce statistically significant changes in brain activity, grey matter volume, or cortical thickness. Cardiovascular fitness, measured by VO2max, was associated with lower grey matter blood flow in the left hippocampus and thicker cortex in the left superior temporal gyrus. Cortical thickness was reduced at post-test independent of exercise/rest. Our findings support that (1) fitter individuals may need lower grey matter blood flow to meet metabolic oxygen demand, and (2) have thicker cortex.Gaia OlivoJonna NilssonBenjamín GarzónAlexander LebedevAnders WåhlinOlga TarassovaMaria M. EkblomMartin LövdénNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gaia Olivo Jonna Nilsson Benjamín Garzón Alexander Lebedev Anders Wåhlin Olga Tarassova Maria M. Ekblom Martin Lövdén Higher VO2max is associated with thicker cortex and lower grey matter blood flow in older adults
description	Abstract VO2max (maximal oxygen consumption), a validated measure of aerobic fitness, has been associated with better cerebral artery compliance and measures of brain morphology, such as higher cortical thickness (CT) in frontal, temporal and cingular cortices, and larger grey matter volume (GMV) of the middle temporal gyrus, hippocampus, orbitofrontal cortex and cingulate cortex. Single sessions of physical exercise can promptly enhance cognitive performance and brain activity during executive tasks. However, the immediate effects of exercise on macro-scale properties of the brain’s grey matter remain unclear. We investigated the impact of one session of moderate-intensity physical exercise, compared with rest, on grey matter volume, cortical thickness, working memory performance, and task-related brain activity in older adults. Cross-sectional associations between brain measures and VO2max were also tested. Exercise did not induce statistically significant changes in brain activity, grey matter volume, or cortical thickness. Cardiovascular fitness, measured by VO2max, was associated with lower grey matter blood flow in the left hippocampus and thicker cortex in the left superior temporal gyrus. Cortical thickness was reduced at post-test independent of exercise/rest. Our findings support that (1) fitter individuals may need lower grey matter blood flow to meet metabolic oxygen demand, and (2) have thicker cortex.
format	article
author	Gaia Olivo Jonna Nilsson Benjamín Garzón Alexander Lebedev Anders Wåhlin Olga Tarassova Maria M. Ekblom Martin Lövdén
author_facet	Gaia Olivo Jonna Nilsson Benjamín Garzón Alexander Lebedev Anders Wåhlin Olga Tarassova Maria M. Ekblom Martin Lövdén
author_sort	Gaia Olivo
title	Higher VO2max is associated with thicker cortex and lower grey matter blood flow in older adults
title_short	Higher VO2max is associated with thicker cortex and lower grey matter blood flow in older adults
title_full	Higher VO2max is associated with thicker cortex and lower grey matter blood flow in older adults
title_fullStr	Higher VO2max is associated with thicker cortex and lower grey matter blood flow in older adults
title_full_unstemmed	Higher VO2max is associated with thicker cortex and lower grey matter blood flow in older adults
title_sort	higher vo2max is associated with thicker cortex and lower grey matter blood flow in older adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/515f4d44d7154ee6ac48405a623f0f7f
work_keys_str_mv	AT gaiaolivo highervo2maxisassociatedwiththickercortexandlowergreymatterbloodflowinolderadults AT jonnanilsson highervo2maxisassociatedwiththickercortexandlowergreymatterbloodflowinolderadults AT benjamingarzon highervo2maxisassociatedwiththickercortexandlowergreymatterbloodflowinolderadults AT alexanderlebedev highervo2maxisassociatedwiththickercortexandlowergreymatterbloodflowinolderadults AT anderswahlin highervo2maxisassociatedwiththickercortexandlowergreymatterbloodflowinolderadults AT olgatarassova highervo2maxisassociatedwiththickercortexandlowergreymatterbloodflowinolderadults AT mariamekblom highervo2maxisassociatedwiththickercortexandlowergreymatterbloodflowinolderadults AT martinlovden highervo2maxisassociatedwiththickercortexandlowergreymatterbloodflowinolderadults
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Higher VO2max is associated with thicker cortex and lower grey matter blood flow in older adults

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