Predictive Value of the Platelet-to-Albumin Ratio (PAR) on the Risk of Death at Admission in Patients Suffering from Severe Fever with Thrombocytopenia Syndrome

Yonghui Gui,1 Yuanhong Xu,2 Peng Yang1 1Department of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, P...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Gui Y, Xu Y, Yang P
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
Acceso en línea:https://doaj.org/article/515fdc52aaa54e27bc39eaa5a9ac1a3d
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:515fdc52aaa54e27bc39eaa5a9ac1a3d
record_format dspace
spelling oai:doaj.org-article:515fdc52aaa54e27bc39eaa5a9ac1a3d2021-12-02T17:26:30ZPredictive Value of the Platelet-to-Albumin Ratio (PAR) on the Risk of Death at Admission in Patients Suffering from Severe Fever with Thrombocytopenia Syndrome1178-7031https://doaj.org/article/515fdc52aaa54e27bc39eaa5a9ac1a3d2021-10-01T00:00:00Zhttps://www.dovepress.com/predictive-value-of-the-platelet-to-albumin-ratio-par-on-the-risk-of-d-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Yonghui Gui,1 Yuanhong Xu,2 Peng Yang1 1Department of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of ChinaCorrespondence: Peng YangDepartment of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of ChinaEmail yangpeng00812@163.comYuanhong XuDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of ChinaEmail xyhong1964@163.comObjective: The purpose of this study was to evaluate the predictive value of the platelet-to-albumin ratio (PAR) on the risk of death in patients with severe fever with thrombocytopenia syndrome.Methods: Between Jan 2019 and June 2021, 127 cases which were admitted to the First Affiliated Hospital of Anhui Medical University have been included in this study. The laboratory data were selected at the time of admission. To identify the potential independent risk factors for severe fever associated with thrombocytopenia syndrome, multivariate logistic regression analysis was performed. Receiver operating characteristic (ROC) curve analysis was used to evaluate the prediction accuracy of PAR in identifying patients exhibiting severe fever with thrombocytopenia syndrome.Results: Multiple logistic regression analysis showed that PAR could potentially serve as an independent risk factor for the death in patients with SFTS (OR = 4.023, 95% CI 1.204– 13.436, P=0.024). The prediction of the risk of death in patients with SFTS was assessed using the AUC. The AUC for the PAR was 0.729 (95% CI, 0.637– 0.82, P < 0.001), whereas the optimal cut-off value of PAR was found to be 1.43, with 54.9% sensitivity and 86.1% specificity.Conclusion: Our study demonstrated for the first time that PAR could act as an independent predictor for mortality in adult patients with SFTS.Keywords: severe fever with thrombocytopenia syndrome, risk factors, platelet-to-albumin ratioGui YXu YYang PDove Medical Pressarticlesevere fever with thrombocytopenia syndromerisk factorsplatelet-to-albumin ratioPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5647-5652 (2021)
institution DOAJ
collection DOAJ
language EN
topic severe fever with thrombocytopenia syndrome
risk factors
platelet-to-albumin ratio
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
spellingShingle severe fever with thrombocytopenia syndrome
risk factors
platelet-to-albumin ratio
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
Gui Y
Xu Y
Yang P
Predictive Value of the Platelet-to-Albumin Ratio (PAR) on the Risk of Death at Admission in Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
description Yonghui Gui,1 Yuanhong Xu,2 Peng Yang1 1Department of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of ChinaCorrespondence: Peng YangDepartment of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of ChinaEmail yangpeng00812@163.comYuanhong XuDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of ChinaEmail xyhong1964@163.comObjective: The purpose of this study was to evaluate the predictive value of the platelet-to-albumin ratio (PAR) on the risk of death in patients with severe fever with thrombocytopenia syndrome.Methods: Between Jan 2019 and June 2021, 127 cases which were admitted to the First Affiliated Hospital of Anhui Medical University have been included in this study. The laboratory data were selected at the time of admission. To identify the potential independent risk factors for severe fever associated with thrombocytopenia syndrome, multivariate logistic regression analysis was performed. Receiver operating characteristic (ROC) curve analysis was used to evaluate the prediction accuracy of PAR in identifying patients exhibiting severe fever with thrombocytopenia syndrome.Results: Multiple logistic regression analysis showed that PAR could potentially serve as an independent risk factor for the death in patients with SFTS (OR = 4.023, 95% CI 1.204– 13.436, P=0.024). The prediction of the risk of death in patients with SFTS was assessed using the AUC. The AUC for the PAR was 0.729 (95% CI, 0.637– 0.82, P < 0.001), whereas the optimal cut-off value of PAR was found to be 1.43, with 54.9% sensitivity and 86.1% specificity.Conclusion: Our study demonstrated for the first time that PAR could act as an independent predictor for mortality in adult patients with SFTS.Keywords: severe fever with thrombocytopenia syndrome, risk factors, platelet-to-albumin ratio
format article
author Gui Y
Xu Y
Yang P
author_facet Gui Y
Xu Y
Yang P
author_sort Gui Y
title Predictive Value of the Platelet-to-Albumin Ratio (PAR) on the Risk of Death at Admission in Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
title_short Predictive Value of the Platelet-to-Albumin Ratio (PAR) on the Risk of Death at Admission in Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
title_full Predictive Value of the Platelet-to-Albumin Ratio (PAR) on the Risk of Death at Admission in Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
title_fullStr Predictive Value of the Platelet-to-Albumin Ratio (PAR) on the Risk of Death at Admission in Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
title_full_unstemmed Predictive Value of the Platelet-to-Albumin Ratio (PAR) on the Risk of Death at Admission in Patients Suffering from Severe Fever with Thrombocytopenia Syndrome
title_sort predictive value of the platelet-to-albumin ratio (par) on the risk of death at admission in patients suffering from severe fever with thrombocytopenia syndrome
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/515fdc52aaa54e27bc39eaa5a9ac1a3d
work_keys_str_mv AT guiy predictivevalueoftheplatelettoalbuminratioparontheriskofdeathatadmissioninpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT xuy predictivevalueoftheplatelettoalbuminratioparontheriskofdeathatadmissioninpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
AT yangp predictivevalueoftheplatelettoalbuminratioparontheriskofdeathatadmissioninpatientssufferingfromseverefeverwiththrombocytopeniasyndrome
_version_ 1718380786799869952