Cytomegalovirus Immunity, Inflammation and Cognitive Abilities in the Elderly

Reducing the socioeconomic toll from age-related physical and mental morbidities requires better understanding of factors affecting healthy aging. While many environmental, lifestyle, and genetic factors affect healthy aging, this study addressed the influence of cytomegalovirus (CMV) infection and...

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Autores principales:	Jacqueline Hesson, Neva Fudge, Michael Grant
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cytomegalovirus immunity inflammation aging cognitive decline fractalkine Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/5161dbca4ebb4cecb30fb6b80ed41c8f
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spelling	oai:doaj.org-article:5161dbca4ebb4cecb30fb6b80ed41c8f2021-11-25T19:14:33ZCytomegalovirus Immunity, Inflammation and Cognitive Abilities in the Elderly10.3390/v131123211999-4915https://doaj.org/article/5161dbca4ebb4cecb30fb6b80ed41c8f2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2321https://doaj.org/toc/1999-4915Reducing the socioeconomic toll from age-related physical and mental morbidities requires better understanding of factors affecting healthy aging. While many environmental, lifestyle, and genetic factors affect healthy aging, this study addressed the influence of cytomegalovirus (CMV) infection and immunity on age-related inflammation and cognitive abilities. Healthy adults 70–90 years old were recruited into a prospective study investigating relationships between anti-CMV immunity, markers of inflammation, baseline measures of cognitive ability, and changes in cognitive ability over 18 months. Humoral and cellular responses against CMV, levels of inflammatory markers, and cognitive abilities were measured at study entry, with measurement of cognitive abilities repeated 18 months later. CMV-seropositive and -seronegative sub-groups were compared, and relationships between anti-CMV immunity, markers of inflammation, and cognitive ability were assessed. Twenty-eight of 39 participants were CMV-seropositive, and two had CMV-specific CD8<sup>+</sup> T cell responses indicative of CMV immune memory inflation. No significant differences for markers of inflammation or measures of cognitive ability were observed between groups, and cognitive scores changed little over 18 months. Significant correlations between markers of inflammation and cognitive scores with interconnection between anti-CMV antibody levels, fractalkine, cognitive ability, and depression scores suggest areas of focus for future studies.Jacqueline HessonNeva FudgeMichael GrantMDPI AGarticlecytomegalovirusimmunityinflammationagingcognitive declinefractalkineMicrobiologyQR1-502ENViruses, Vol 13, Iss 2321, p 2321 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytomegalovirus immunity inflammation aging cognitive decline fractalkine Microbiology QR1-502
spellingShingle	cytomegalovirus immunity inflammation aging cognitive decline fractalkine Microbiology QR1-502 Jacqueline Hesson Neva Fudge Michael Grant Cytomegalovirus Immunity, Inflammation and Cognitive Abilities in the Elderly
description	Reducing the socioeconomic toll from age-related physical and mental morbidities requires better understanding of factors affecting healthy aging. While many environmental, lifestyle, and genetic factors affect healthy aging, this study addressed the influence of cytomegalovirus (CMV) infection and immunity on age-related inflammation and cognitive abilities. Healthy adults 70–90 years old were recruited into a prospective study investigating relationships between anti-CMV immunity, markers of inflammation, baseline measures of cognitive ability, and changes in cognitive ability over 18 months. Humoral and cellular responses against CMV, levels of inflammatory markers, and cognitive abilities were measured at study entry, with measurement of cognitive abilities repeated 18 months later. CMV-seropositive and -seronegative sub-groups were compared, and relationships between anti-CMV immunity, markers of inflammation, and cognitive ability were assessed. Twenty-eight of 39 participants were CMV-seropositive, and two had CMV-specific CD8<sup>+</sup> T cell responses indicative of CMV immune memory inflation. No significant differences for markers of inflammation or measures of cognitive ability were observed between groups, and cognitive scores changed little over 18 months. Significant correlations between markers of inflammation and cognitive scores with interconnection between anti-CMV antibody levels, fractalkine, cognitive ability, and depression scores suggest areas of focus for future studies.
format	article
author	Jacqueline Hesson Neva Fudge Michael Grant
author_facet	Jacqueline Hesson Neva Fudge Michael Grant
author_sort	Jacqueline Hesson
title	Cytomegalovirus Immunity, Inflammation and Cognitive Abilities in the Elderly
title_short	Cytomegalovirus Immunity, Inflammation and Cognitive Abilities in the Elderly
title_full	Cytomegalovirus Immunity, Inflammation and Cognitive Abilities in the Elderly
title_fullStr	Cytomegalovirus Immunity, Inflammation and Cognitive Abilities in the Elderly
title_full_unstemmed	Cytomegalovirus Immunity, Inflammation and Cognitive Abilities in the Elderly
title_sort	cytomegalovirus immunity, inflammation and cognitive abilities in the elderly
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5161dbca4ebb4cecb30fb6b80ed41c8f
work_keys_str_mv	AT jacquelinehesson cytomegalovirusimmunityinflammationandcognitiveabilitiesintheelderly AT nevafudge cytomegalovirusimmunityinflammationandcognitiveabilitiesintheelderly AT michaelgrant cytomegalovirusimmunityinflammationandcognitiveabilitiesintheelderly
_version_	1718410090206199808

Cytomegalovirus Immunity, Inflammation and Cognitive Abilities in the Elderly

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