Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins

Abstract Diabetes mellitus is a complex and heterogeneous metabolic disorder which is often pre- or post-existent with complications such as cardiovascular disease, hypertension, inflammation, chronic kidney disease, diabetic retino- and nephropathies. However, the frequencies of these co-morbiditie...

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Autores principales:	Sabrina Samad Shoily, Tamim Ahsan, Kaniz Fatema, Abu Ashfaqur Sajib
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/516778d297354487b20ca17bd297081b
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spelling	oai:doaj.org-article:516778d297354487b20ca17bd297081b2021-12-02T14:37:40ZCommon genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins10.1038/s41598-021-86801-22045-2322https://doaj.org/article/516778d297354487b20ca17bd297081b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86801-2https://doaj.org/toc/2045-2322Abstract Diabetes mellitus is a complex and heterogeneous metabolic disorder which is often pre- or post-existent with complications such as cardiovascular disease, hypertension, inflammation, chronic kidney disease, diabetic retino- and nephropathies. However, the frequencies of these co-morbidities vary among individuals and across populations. It is, therefore, not unlikely that certain genetic variants might commonly contribute to these conditions. Here, we identified four single nucleotide polymorphisms (rs5186, rs1800795, rs1799983 and rs1800629 in AGTR1, IL6, NOS3 and TNFA genes, respectively) to be commonly associated with each of these conditions. We explored their possible interplay in diabetes and associated complications. The variant allele and haplotype frequencies at these polymorphic loci vary among different super-populations (African, European, admixed Americans, South and East Asians). The variant alleles are particularly highly prevalent in different European and admixed American populations. Differential distribution of these variants in different ethnic groups suggests that certain drugs might be more effective in selective populations rather than all. Therefore, population specific genetic architectures should be considered before considering a drug for these conditions.Sabrina Samad ShoilyTamim AhsanKaniz FatemaAbu Ashfaqur SajibNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sabrina Samad Shoily Tamim Ahsan Kaniz Fatema Abu Ashfaqur Sajib Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins
description	Abstract Diabetes mellitus is a complex and heterogeneous metabolic disorder which is often pre- or post-existent with complications such as cardiovascular disease, hypertension, inflammation, chronic kidney disease, diabetic retino- and nephropathies. However, the frequencies of these co-morbidities vary among individuals and across populations. It is, therefore, not unlikely that certain genetic variants might commonly contribute to these conditions. Here, we identified four single nucleotide polymorphisms (rs5186, rs1800795, rs1799983 and rs1800629 in AGTR1, IL6, NOS3 and TNFA genes, respectively) to be commonly associated with each of these conditions. We explored their possible interplay in diabetes and associated complications. The variant allele and haplotype frequencies at these polymorphic loci vary among different super-populations (African, European, admixed Americans, South and East Asians). The variant alleles are particularly highly prevalent in different European and admixed American populations. Differential distribution of these variants in different ethnic groups suggests that certain drugs might be more effective in selective populations rather than all. Therefore, population specific genetic architectures should be considered before considering a drug for these conditions.
format	article
author	Sabrina Samad Shoily Tamim Ahsan Kaniz Fatema Abu Ashfaqur Sajib
author_facet	Sabrina Samad Shoily Tamim Ahsan Kaniz Fatema Abu Ashfaqur Sajib
author_sort	Sabrina Samad Shoily
title	Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins
title_short	Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins
title_full	Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins
title_fullStr	Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins
title_full_unstemmed	Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins
title_sort	common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/516778d297354487b20ca17bd297081b
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Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins

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