Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization

Optimisation of nucleic acid probes and blocker strands can be laborious. Here the authors construct a theoretical model of competitive DNA hybridisation to design DNA probes for optimisation-free mutation detection.

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Autores principales:	Xin Chen, Na Liu, Liquan Liu, Wei Chen, Na Chen, Meng Lin, Jiaju Xu, Xing Zhou, Hongbo Wang, Meiping Zhao, Xianjin Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/51692b9b0b4546f3a6c6b9e302c3c683
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spelling	oai:doaj.org-article:51692b9b0b4546f3a6c6b9e302c3c6832021-12-02T14:39:41ZThermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization10.1038/s41467-019-12593-92041-1723https://doaj.org/article/51692b9b0b4546f3a6c6b9e302c3c6832019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12593-9https://doaj.org/toc/2041-1723Optimisation of nucleic acid probes and blocker strands can be laborious. Here the authors construct a theoretical model of competitive DNA hybridisation to design DNA probes for optimisation-free mutation detection.Xin ChenNa LiuLiquan LiuWei ChenNa ChenMeng LinJiaju XuXing ZhouHongbo WangMeiping ZhaoXianjin XiaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xin Chen Na Liu Liquan Liu Wei Chen Na Chen Meng Lin Jiaju Xu Xing Zhou Hongbo Wang Meiping Zhao Xianjin Xiao Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization
description	Optimisation of nucleic acid probes and blocker strands can be laborious. Here the authors construct a theoretical model of competitive DNA hybridisation to design DNA probes for optimisation-free mutation detection.
format	article
author	Xin Chen Na Liu Liquan Liu Wei Chen Na Chen Meng Lin Jiaju Xu Xing Zhou Hongbo Wang Meiping Zhao Xianjin Xiao
author_facet	Xin Chen Na Liu Liquan Liu Wei Chen Na Chen Meng Lin Jiaju Xu Xing Zhou Hongbo Wang Meiping Zhao Xianjin Xiao
author_sort	Xin Chen
title	Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization
title_short	Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization
title_full	Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization
title_fullStr	Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization
title_full_unstemmed	Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization
title_sort	thermodynamics and kinetics guided probe design for uniformly sensitive and specific dna hybridization without optimization
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/51692b9b0b4546f3a6c6b9e302c3c683
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_version_	1718390530102001664

Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization

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