Impact of Prior Statin Use on Reperfusion Rate and Stroke Outcomes in Patients Receiving Endovascular Treatment

Background: We evaluated the impact of prior statin use on successful reperfusion and stroke outcomes after endovascular treatment (EVT). Method: Using consecutive multicenter databases, we enrolled acute ischemic stroke patients receiving EVT between 2015 and 2021. Patients were classified into pri...

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Autores principales:	Sang-Hwa Lee, Min Uk Jang, Yerim Kim, So Young Park, Chulho Kim, Yeo Jin Kim, Jong-Hee Sohn
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prior statin endovascular treatment reperfusion rate early neurologic deterioration stroke outcome Medicine R
Acceso en línea:	https://doaj.org/article/516a0381786148aab2a26e0fa3784fa7
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spelling	oai:doaj.org-article:516a0381786148aab2a26e0fa3784fa72021-11-11T17:46:20ZImpact of Prior Statin Use on Reperfusion Rate and Stroke Outcomes in Patients Receiving Endovascular Treatment10.3390/jcm102151472077-0383https://doaj.org/article/516a0381786148aab2a26e0fa3784fa72021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5147https://doaj.org/toc/2077-0383Background: We evaluated the impact of prior statin use on successful reperfusion and stroke outcomes after endovascular treatment (EVT). Method: Using consecutive multicenter databases, we enrolled acute ischemic stroke patients receiving EVT between 2015 and 2021. Patients were classified into prior statin users and no prior statin users after a review of premorbid medications. The primary outcome measure was successful reperfusion defined as modified TICI grade 2b or 3 after EVT. Secondary outcome measures were early neurologic deterioration (END) and a 3-month modified Rankin Scale (mRS) score of 0 to 2. Results: Among 385 patients receiving EVT, 74 (19.2%) were prior statin users, who had a significantly higher successful reperfusion rate compared with no prior statin users (94.6% versus 78.8%, <i>p</i> = 0.002). Successful reperfusion and END occurrence were improved according to statin intensity with a dose–response relationship. In multivariate analysis, prior statin was associated with successful reperfusion after EVT (adjusted odds ratio (95% confidence interval) 5.31 (1.67–16.86)). In addition, prior statin was associated with a lower occurrence of END and good functional status. Conclusion: Our study showed that prior statin use before ischemic stroke might improve successful reperfusion and stroke outcomes after EVT.Sang-Hwa LeeMin Uk JangYerim KimSo Young ParkChulho KimYeo Jin KimJong-Hee SohnMDPI AGarticleprior statinendovascular treatmentreperfusion rateearly neurologic deteriorationstroke outcomeMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5147, p 5147 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prior statin endovascular treatment reperfusion rate early neurologic deterioration stroke outcome Medicine R
spellingShingle	prior statin endovascular treatment reperfusion rate early neurologic deterioration stroke outcome Medicine R Sang-Hwa Lee Min Uk Jang Yerim Kim So Young Park Chulho Kim Yeo Jin Kim Jong-Hee Sohn Impact of Prior Statin Use on Reperfusion Rate and Stroke Outcomes in Patients Receiving Endovascular Treatment
description	Background: We evaluated the impact of prior statin use on successful reperfusion and stroke outcomes after endovascular treatment (EVT). Method: Using consecutive multicenter databases, we enrolled acute ischemic stroke patients receiving EVT between 2015 and 2021. Patients were classified into prior statin users and no prior statin users after a review of premorbid medications. The primary outcome measure was successful reperfusion defined as modified TICI grade 2b or 3 after EVT. Secondary outcome measures were early neurologic deterioration (END) and a 3-month modified Rankin Scale (mRS) score of 0 to 2. Results: Among 385 patients receiving EVT, 74 (19.2%) were prior statin users, who had a significantly higher successful reperfusion rate compared with no prior statin users (94.6% versus 78.8%, <i>p</i> = 0.002). Successful reperfusion and END occurrence were improved according to statin intensity with a dose–response relationship. In multivariate analysis, prior statin was associated with successful reperfusion after EVT (adjusted odds ratio (95% confidence interval) 5.31 (1.67–16.86)). In addition, prior statin was associated with a lower occurrence of END and good functional status. Conclusion: Our study showed that prior statin use before ischemic stroke might improve successful reperfusion and stroke outcomes after EVT.
format	article
author	Sang-Hwa Lee Min Uk Jang Yerim Kim So Young Park Chulho Kim Yeo Jin Kim Jong-Hee Sohn
author_facet	Sang-Hwa Lee Min Uk Jang Yerim Kim So Young Park Chulho Kim Yeo Jin Kim Jong-Hee Sohn
author_sort	Sang-Hwa Lee
title	Impact of Prior Statin Use on Reperfusion Rate and Stroke Outcomes in Patients Receiving Endovascular Treatment
title_short	Impact of Prior Statin Use on Reperfusion Rate and Stroke Outcomes in Patients Receiving Endovascular Treatment
title_full	Impact of Prior Statin Use on Reperfusion Rate and Stroke Outcomes in Patients Receiving Endovascular Treatment
title_fullStr	Impact of Prior Statin Use on Reperfusion Rate and Stroke Outcomes in Patients Receiving Endovascular Treatment
title_full_unstemmed	Impact of Prior Statin Use on Reperfusion Rate and Stroke Outcomes in Patients Receiving Endovascular Treatment
title_sort	impact of prior statin use on reperfusion rate and stroke outcomes in patients receiving endovascular treatment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/516a0381786148aab2a26e0fa3784fa7
work_keys_str_mv	AT sanghwalee impactofpriorstatinuseonreperfusionrateandstrokeoutcomesinpatientsreceivingendovasculartreatment AT minukjang impactofpriorstatinuseonreperfusionrateandstrokeoutcomesinpatientsreceivingendovasculartreatment AT yerimkim impactofpriorstatinuseonreperfusionrateandstrokeoutcomesinpatientsreceivingendovasculartreatment AT soyoungpark impactofpriorstatinuseonreperfusionrateandstrokeoutcomesinpatientsreceivingendovasculartreatment AT chulhokim impactofpriorstatinuseonreperfusionrateandstrokeoutcomesinpatientsreceivingendovasculartreatment AT yeojinkim impactofpriorstatinuseonreperfusionrateandstrokeoutcomesinpatientsreceivingendovasculartreatment AT jongheesohn impactofpriorstatinuseonreperfusionrateandstrokeoutcomesinpatientsreceivingendovasculartreatment
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Impact of Prior Statin Use on Reperfusion Rate and Stroke Outcomes in Patients Receiving Endovascular Treatment

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