8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer

Inherited alterations of the 8q24 genomic locus are linked to cancer etiology. Here, the authors investigate hereditary prostate cancer to reveal ancestral risk-altering haplotypes, the sentinel genetic variants optimally predicting risk, and causal mutation candidates.

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Autores principales:	William D. Dupont, Joan P. Breyer, W. Dale Plummer, Sam S. Chang, Michael S. Cookson, Joseph A. Smith, University of Washington Center for Mendelian Genomics, Elizabeth E. Blue, Michael J. Bamshad, Jeffrey R. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/516b649d3bb74353b9d7764b84ffcce6
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spelling	oai:doaj.org-article:516b649d3bb74353b9d7764b84ffcce62021-12-02T17:31:38Z8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer10.1038/s41467-020-15122-12041-1723https://doaj.org/article/516b649d3bb74353b9d7764b84ffcce62020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15122-1https://doaj.org/toc/2041-1723Inherited alterations of the 8q24 genomic locus are linked to cancer etiology. Here, the authors investigate hereditary prostate cancer to reveal ancestral risk-altering haplotypes, the sentinel genetic variants optimally predicting risk, and causal mutation candidates.William D. DupontJoan P. BreyerW. Dale PlummerSam S. ChangMichael S. CooksonJoseph A. SmithUniversity of Washington Center for Mendelian GenomicsElizabeth E. BlueMichael J. BamshadJeffrey R. SmithNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William D. Dupont Joan P. Breyer W. Dale Plummer Sam S. Chang Michael S. Cookson Joseph A. Smith University of Washington Center for Mendelian Genomics Elizabeth E. Blue Michael J. Bamshad Jeffrey R. Smith 8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer
description	Inherited alterations of the 8q24 genomic locus are linked to cancer etiology. Here, the authors investigate hereditary prostate cancer to reveal ancestral risk-altering haplotypes, the sentinel genetic variants optimally predicting risk, and causal mutation candidates.
format	article
author	William D. Dupont Joan P. Breyer W. Dale Plummer Sam S. Chang Michael S. Cookson Joseph A. Smith University of Washington Center for Mendelian Genomics Elizabeth E. Blue Michael J. Bamshad Jeffrey R. Smith
author_facet	William D. Dupont Joan P. Breyer W. Dale Plummer Sam S. Chang Michael S. Cookson Joseph A. Smith University of Washington Center for Mendelian Genomics Elizabeth E. Blue Michael J. Bamshad Jeffrey R. Smith
author_sort	William D. Dupont
title	8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer
title_short	8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer
title_full	8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer
title_fullStr	8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer
title_full_unstemmed	8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer
title_sort	8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/516b649d3bb74353b9d7764b84ffcce6
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8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer

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