8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer

8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer

Inherited alterations of the 8q24 genomic locus are linked to cancer etiology. Here, the authors investigate hereditary prostate cancer to reveal ancestral risk-altering haplotypes, the sentinel genetic variants optimally predicting risk, and causal mutation candidates.

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Detalles Bibliográficos
Autores principales: William D. Dupont, Joan P. Breyer, W. Dale Plummer, Sam S. Chang, Michael S. Cookson, Joseph A. Smith, University of Washington Center for Mendelian Genomics, Elizabeth E. Blue, Michael J. Bamshad, Jeffrey R. Smith
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/516b649d3bb74353b9d7764b84ffcce6
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https://doaj.org/article/516b649d3bb74353b9d7764b84ffcce6

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