Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation

It is unclear how embryonic stem cells (ESC) communicate with surrounding cells during implantation. Here, the authors show that microvesicles (MV) are shed from ESCs, activating integrin and JNK/FAK kinases in trophoblasts, stimulating migration in vitro, and injecting MVs enhances blastocyst impla...

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Main Authors:	Laura M. Desrochers, François Bordeleau, Cynthia A. Reinhart-King, Richard A. Cerione, Marc A. Antonyak
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/516c8dc9e73e4c0e8fffed135eef3048
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spelling	oai:doaj.org-article:516c8dc9e73e4c0e8fffed135eef30482021-12-02T15:34:33ZMicrovesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation10.1038/ncomms119582041-1723https://doaj.org/article/516c8dc9e73e4c0e8fffed135eef30482016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11958https://doaj.org/toc/2041-1723It is unclear how embryonic stem cells (ESC) communicate with surrounding cells during implantation. Here, the authors show that microvesicles (MV) are shed from ESCs, activating integrin and JNK/FAK kinases in trophoblasts, stimulating migration in vitro, and injecting MVs enhances blastocyst implantation.Laura M. DesrochersFrançois BordeleauCynthia A. Reinhart-KingRichard A. CerioneMarc A. AntonyakNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura M. Desrochers François Bordeleau Cynthia A. Reinhart-King Richard A. Cerione Marc A. Antonyak Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation
description	It is unclear how embryonic stem cells (ESC) communicate with surrounding cells during implantation. Here, the authors show that microvesicles (MV) are shed from ESCs, activating integrin and JNK/FAK kinases in trophoblasts, stimulating migration in vitro, and injecting MVs enhances blastocyst implantation.
format	article
author	Laura M. Desrochers François Bordeleau Cynthia A. Reinhart-King Richard A. Cerione Marc A. Antonyak
author_facet	Laura M. Desrochers François Bordeleau Cynthia A. Reinhart-King Richard A. Cerione Marc A. Antonyak
author_sort	Laura M. Desrochers
title	Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation
title_short	Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation
title_full	Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation
title_fullStr	Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation
title_full_unstemmed	Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation
title_sort	microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/516c8dc9e73e4c0e8fffed135eef3048
work_keys_str_mv	AT lauramdesrochers microvesiclesprovideamechanismforintercellularcommunicationbyembryonicstemcellsduringembryoimplantation AT francoisbordeleau microvesiclesprovideamechanismforintercellularcommunicationbyembryonicstemcellsduringembryoimplantation AT cynthiaareinhartking microvesiclesprovideamechanismforintercellularcommunicationbyembryonicstemcellsduringembryoimplantation AT richardacerione microvesiclesprovideamechanismforintercellularcommunicationbyembryonicstemcellsduringembryoimplantation AT marcaantonyak microvesiclesprovideamechanismforintercellularcommunicationbyembryonicstemcellsduringembryoimplantation
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Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation

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