Next-Generation High-Throughput Functional Annotation of Microbial Genomes

ABSTRACT Host infection by microbial pathogens cues global changes in microbial and host cell biology that facilitate microbial replication and disease. The complete maps of thousands of bacterial and viral genomes have recently been defined; however, the rate at which physiological or biochemical f...

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Autores principales:	Ralph S. Baric, Sean Crosson, Blossom Damania, Samuel I. Miller, Eric J. Rubin
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/516ede72380646ce9c2c77b8595f212e
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spelling	oai:doaj.org-article:516ede72380646ce9c2c77b8595f212e2021-11-15T15:50:16ZNext-Generation High-Throughput Functional Annotation of Microbial Genomes10.1128/mBio.01245-162150-7511https://doaj.org/article/516ede72380646ce9c2c77b8595f212e2016-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01245-16https://doaj.org/toc/2150-7511ABSTRACT Host infection by microbial pathogens cues global changes in microbial and host cell biology that facilitate microbial replication and disease. The complete maps of thousands of bacterial and viral genomes have recently been defined; however, the rate at which physiological or biochemical functions have been assigned to genes has greatly lagged. The National Institute of Allergy and Infectious Diseases (NIAID) addressed this gap by creating functional genomics centers dedicated to developing high-throughput approaches to assign gene function. These centers require broad-based and collaborative research programs to generate and integrate diverse data to achieve a comprehensive understanding of microbial pathogenesis. High-throughput functional genomics can lead to new therapeutics and better understanding of the next generation of emerging pathogens by rapidly defining new general mechanisms by which organisms cause disease and replicate in host tissues and by facilitating the rate at which functional data reach the scientific community.Ralph S. BaricSean CrossonBlossom DamaniaSamuel I. MillerEric J. RubinAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 5 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Ralph S. Baric Sean Crosson Blossom Damania Samuel I. Miller Eric J. Rubin Next-Generation High-Throughput Functional Annotation of Microbial Genomes
description	ABSTRACT Host infection by microbial pathogens cues global changes in microbial and host cell biology that facilitate microbial replication and disease. The complete maps of thousands of bacterial and viral genomes have recently been defined; however, the rate at which physiological or biochemical functions have been assigned to genes has greatly lagged. The National Institute of Allergy and Infectious Diseases (NIAID) addressed this gap by creating functional genomics centers dedicated to developing high-throughput approaches to assign gene function. These centers require broad-based and collaborative research programs to generate and integrate diverse data to achieve a comprehensive understanding of microbial pathogenesis. High-throughput functional genomics can lead to new therapeutics and better understanding of the next generation of emerging pathogens by rapidly defining new general mechanisms by which organisms cause disease and replicate in host tissues and by facilitating the rate at which functional data reach the scientific community.
format	article
author	Ralph S. Baric Sean Crosson Blossom Damania Samuel I. Miller Eric J. Rubin
author_facet	Ralph S. Baric Sean Crosson Blossom Damania Samuel I. Miller Eric J. Rubin
author_sort	Ralph S. Baric
title	Next-Generation High-Throughput Functional Annotation of Microbial Genomes
title_short	Next-Generation High-Throughput Functional Annotation of Microbial Genomes
title_full	Next-Generation High-Throughput Functional Annotation of Microbial Genomes
title_fullStr	Next-Generation High-Throughput Functional Annotation of Microbial Genomes
title_full_unstemmed	Next-Generation High-Throughput Functional Annotation of Microbial Genomes
title_sort	next-generation high-throughput functional annotation of microbial genomes
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/516ede72380646ce9c2c77b8595f212e
work_keys_str_mv	AT ralphsbaric nextgenerationhighthroughputfunctionalannotationofmicrobialgenomes AT seancrosson nextgenerationhighthroughputfunctionalannotationofmicrobialgenomes AT blossomdamania nextgenerationhighthroughputfunctionalannotationofmicrobialgenomes AT samuelimiller nextgenerationhighthroughputfunctionalannotationofmicrobialgenomes AT ericjrubin nextgenerationhighthroughputfunctionalannotationofmicrobialgenomes
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Next-Generation High-Throughput Functional Annotation of Microbial Genomes

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