Conserved epitopes with high HLA-I population coverage are targets of CD8+ T cells associated with high IFN-γ responses against all dengue virus serotypes

Conserved epitopes with high HLA-I population coverage are targets of CD8+ T cells associated with high IFN-γ responses against all dengue virus serotypes

Abstract Cytotoxic CD8+ T cells are key for immune protection against viral infections. The breadth and cross-reactivity of these responses are important against rapidly mutating RNA viruses, such as dengue (DENV), yet how viral diversity affect T cell responses and their cross-reactivity against mu...

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Autores principales: Thiruni N. Adikari, Francesca Di Giallonardo, Preston Leung, Alba Grifoni, Alex Sette, Daniela Weiskopf, Rowena A. Bull, Fabio Luciani
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/51745d141be148b08de2cd69f032174f
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