A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes

Validating crosslinking-mass spectrometry workflows is hampered by the lack of a ground truth to assess the robustness of the crosslink identifications. Here, the authors present a synthetic library of crosslinked peptides, enabling unambiguous discrimination of correct and incorrect crosslink ident...

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Autores principales:	Rebecca Beveridge, Johannes Stadlmann, Josef M. Penninger, Karl Mechtler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/51759c8d309249a39e0926ce4db32372
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spelling	oai:doaj.org-article:51759c8d309249a39e0926ce4db323722021-12-02T16:49:30ZA synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes10.1038/s41467-020-14608-22041-1723https://doaj.org/article/51759c8d309249a39e0926ce4db323722020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14608-2https://doaj.org/toc/2041-1723Validating crosslinking-mass spectrometry workflows is hampered by the lack of a ground truth to assess the robustness of the crosslink identifications. Here, the authors present a synthetic library of crosslinked peptides, enabling unambiguous discrimination of correct and incorrect crosslink identifications.Rebecca BeveridgeJohannes StadlmannJosef M. PenningerKarl MechtlerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca Beveridge Johannes Stadlmann Josef M. Penninger Karl Mechtler A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes
description	Validating crosslinking-mass spectrometry workflows is hampered by the lack of a ground truth to assess the robustness of the crosslink identifications. Here, the authors present a synthetic library of crosslinked peptides, enabling unambiguous discrimination of correct and incorrect crosslink identifications.
format	article
author	Rebecca Beveridge Johannes Stadlmann Josef M. Penninger Karl Mechtler
author_facet	Rebecca Beveridge Johannes Stadlmann Josef M. Penninger Karl Mechtler
author_sort	Rebecca Beveridge
title	A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes
title_short	A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes
title_full	A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes
title_fullStr	A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes
title_full_unstemmed	A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes
title_sort	synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/51759c8d309249a39e0926ce4db32372
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A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes

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