A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes

Validating crosslinking-mass spectrometry workflows is hampered by the lack of a ground truth to assess the robustness of the crosslink identifications. Here, the authors present a synthetic library of crosslinked peptides, enabling unambiguous discrimination of correct and incorrect crosslink ident...

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Autores principales: Rebecca Beveridge, Johannes Stadlmann, Josef M. Penninger, Karl Mechtler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/51759c8d309249a39e0926ce4db32372
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