Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins

Macroautophagy can regulate cell signalling and tumorigenesis but the molecular mechanisms are unclear. Here the authors show selective degradation of the signalling scaffold TRAF3 by autophagy and consequent activation of the NF-κB family member RELB regulate gene expression via antagonism of SMAD...

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Autores principales:	Alice C. Newman, Alain J. Kemp, Yvette Drabsch, Christian Behrends, Simon Wilkinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/517692c5851844229fcf533d939a706e
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spelling	oai:doaj.org-article:517692c5851844229fcf533d939a706e2021-12-02T14:42:43ZAutophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins10.1038/s41467-017-00859-z2041-1723https://doaj.org/article/517692c5851844229fcf533d939a706e2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00859-zhttps://doaj.org/toc/2041-1723Macroautophagy can regulate cell signalling and tumorigenesis but the molecular mechanisms are unclear. Here the authors show selective degradation of the signalling scaffold TRAF3 by autophagy and consequent activation of the NF-κB family member RELB regulate gene expression via antagonism of SMAD proteins.Alice C. NewmanAlain J. KempYvette DrabschChristian BehrendsSimon WilkinsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alice C. Newman Alain J. Kemp Yvette Drabsch Christian Behrends Simon Wilkinson Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins
description	Macroautophagy can regulate cell signalling and tumorigenesis but the molecular mechanisms are unclear. Here the authors show selective degradation of the signalling scaffold TRAF3 by autophagy and consequent activation of the NF-κB family member RELB regulate gene expression via antagonism of SMAD proteins.
format	article
author	Alice C. Newman Alain J. Kemp Yvette Drabsch Christian Behrends Simon Wilkinson
author_facet	Alice C. Newman Alain J. Kemp Yvette Drabsch Christian Behrends Simon Wilkinson
author_sort	Alice C. Newman
title	Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins
title_short	Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins
title_full	Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins
title_fullStr	Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins
title_full_unstemmed	Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins
title_sort	autophagy acts through traf3 and relb to regulate gene expression via antagonism of smad proteins
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/517692c5851844229fcf533d939a706e
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Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins

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