Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins
Macroautophagy can regulate cell signalling and tumorigenesis but the molecular mechanisms are unclear. Here the authors show selective degradation of the signalling scaffold TRAF3 by autophagy and consequent activation of the NF-κB family member RELB regulate gene expression via antagonism of SMAD...
Guardado en:
Autores principales: | Alice C. Newman, Alain J. Kemp, Yvette Drabsch, Christian Behrends, Simon Wilkinson |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/517692c5851844229fcf533d939a706e |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules.
por: Min Yang, et al.
Publicado: (2010) -
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
por: Tânia D. F. Costa, et al.
Publicado: (2019) -
A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis
por: Guilhem Lalle, et al.
Publicado: (2021) -
JNK regulates muscle remodeling via myostatin/SMAD inhibition
por: Sarah J. Lessard, et al.
Publicado: (2018) -
TRAF3 negatively regulates platelet activation and thrombosis
por: Rui Zhang, et al.
Publicado: (2017)