Detection of Cytosolic <italic toggle="yes">Shigella flexneri</italic> via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility

ABSTRACT Dynamin-like guanylate binding proteins (GBPs) are gamma interferon (IFN-γ)-inducible host defense proteins that can associate with cytosol-invading bacterial pathogens. Mouse GBPs promote the lytic destruction of targeted bacteria in the host cell cytosol, but the antimicrobial function of...

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Autores principales: Anthony S. Piro, Dulcemaria Hernandez, Sarah Luoma, Eric M. Feeley, Ryan Finethy, Azeb Yirga, Eva M. Frickel, Cammie F. Lesser, Jörn Coers
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
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Acceso en línea:https://doaj.org/article/51771ab8e9bf43aaa2843d2a7d4c7174
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