Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy

Xiang-Hong Peng1,4, Ximei Qian2,4, Hui Mao3,4, Andrew Y Wang5, Zhuo (Georgia) Chen1,4, Shuming Nie2,4, Dong M Shin1,4*1Department of Medical Oncology/Hematology; 2Department of Biomedical Engineering; 3Department of Radiology; 4Winship Cancer Institute, Emory University School of Medicine, Atlanta,...

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Autores principales:	Xiang-Hong Peng, Ximei Qian, Hui Mao, Andrew Y Wang, Zhuo (Georgia) Chen, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/517758b7535b4ab58af42b4f5c978c95
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spelling	oai:doaj.org-article:517758b7535b4ab58af42b4f5c978c952021-12-02T02:42:07ZTargeted magnetic iron oxide nanoparticles for tumor imaging and therapy1176-91141178-2013https://doaj.org/article/517758b7535b4ab58af42b4f5c978c952008-10-01T00:00:00Zhttp://www.dovepress.com/targeted-magnetic-iron-oxide-nanoparticles-for-tumor-imaging-and-thera-a2429https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Xiang-Hong Peng1,4, Ximei Qian2,4, Hui Mao3,4, Andrew Y Wang5, Zhuo (Georgia) Chen1,4, Shuming Nie2,4, Dong M Shin1,41Department of Medical Oncology/Hematology; 2Department of Biomedical Engineering; 3Department of Radiology; 4Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA; 5Ocean Nanotech, LLC, Fayetteville, AR, USAAbstract: Magnetic iron oxide (IO) nanoparticles with a long blood retention time, biodegradability and low toxicity have emerged as one of the primary nanomaterials for biomedical applications in vitro and in vivo. IO nanoparticles have a large surface area and can be engineered to provide a large number of functional groups&nbsp;for cross-linking to tumor-targeting ligands such as monoclonal antibodies, peptides, or small molecules for diagnostic imaging or delivery of therapeutic agents. IO nanoparticles possess unique paramagnetic properties, which generate significant susceptibility effects resulting in strong T2 and T2 contrast, as well as T1 effects at very low concentrations for magnetic resonance imaging (MRI), which is widely used for clinical oncology imaging. We review recent advances in the development of targeted IO nanoparticles for tumor imaging and therapy.Keywords: iron oxide nanoparticles, tumor imaging, MRI, therapy Xiang-Hong PengXimei QianHui MaoAndrew Y WangZhuo (Georgia) Chenet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 3, Pp 311-321 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xiang-Hong Peng Ximei Qian Hui Mao Andrew Y Wang Zhuo (Georgia) Chen et al Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
description	Xiang-Hong Peng1,4, Ximei Qian2,4, Hui Mao3,4, Andrew Y Wang5, Zhuo (Georgia) Chen1,4, Shuming Nie2,4, Dong M Shin1,41Department of Medical Oncology/Hematology; 2Department of Biomedical Engineering; 3Department of Radiology; 4Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA; 5Ocean Nanotech, LLC, Fayetteville, AR, USAAbstract: Magnetic iron oxide (IO) nanoparticles with a long blood retention time, biodegradability and low toxicity have emerged as one of the primary nanomaterials for biomedical applications in vitro and in vivo. IO nanoparticles have a large surface area and can be engineered to provide a large number of functional groups&nbsp;for cross-linking to tumor-targeting ligands such as monoclonal antibodies, peptides, or small molecules for diagnostic imaging or delivery of therapeutic agents. IO nanoparticles possess unique paramagnetic properties, which generate significant susceptibility effects resulting in strong T2 and T2 contrast, as well as T1 effects at very low concentrations for magnetic resonance imaging (MRI), which is widely used for clinical oncology imaging. We review recent advances in the development of targeted IO nanoparticles for tumor imaging and therapy.Keywords: iron oxide nanoparticles, tumor imaging, MRI, therapy
format	article
author	Xiang-Hong Peng Ximei Qian Hui Mao Andrew Y Wang Zhuo (Georgia) Chen et al
author_facet	Xiang-Hong Peng Ximei Qian Hui Mao Andrew Y Wang Zhuo (Georgia) Chen et al
author_sort	Xiang-Hong Peng
title	Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
title_short	Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
title_full	Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
title_fullStr	Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
title_full_unstemmed	Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
title_sort	targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/517758b7535b4ab58af42b4f5c978c95
work_keys_str_mv	AT xianghongpeng targetedmagneticironoxidenanoparticlesfortumorimagingandtherapy AT ximeiqian targetedmagneticironoxidenanoparticlesfortumorimagingandtherapy AT huimao targetedmagneticironoxidenanoparticlesfortumorimagingandtherapy AT andrewywang targetedmagneticironoxidenanoparticlesfortumorimagingandtherapy AT zhuogeorgiachen targetedmagneticironoxidenanoparticlesfortumorimagingandtherapy AT etal targetedmagneticironoxidenanoparticlesfortumorimagingandtherapy
_version_	1718402218145611776

Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy

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